[HTML][HTML] Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
…, F Bevilacqua, M Luchetti, T Spadoni… - … England Journal of …, 2006 - Mass Medical Soc
Background Systemic sclerosis (scleroderma) is characterized by immunologic abnormalities,
injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been …
injury of endothelial cells, and tissue fibrosis. Abnormal oxidative stress has been …
Microplastics and nanoplastics in atheromas and cardiovascular events
…, G Fulgenzi, L Graciotti, T Spadoni… - … England Journal of …, 2024 - Mass Medical Soc
Background Microplastics and nanoplastics (MNPs) are emerging as a potential risk factor
for cardiovascular disease in preclinical studies. Direct evidence that this risk extends to …
for cardiovascular disease in preclinical studies. Direct evidence that this risk extends to …
Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis
S Svegliati, G Marrone, A Pezone, T Spadoni… - Science …, 2014 - science.org
Systemic sclerosis (SSc) is an autoimmune disease characterized by extensive visceral organ
and skin fibrosis. SSc patients have increased production of autoreactive antibodies and …
and skin fibrosis. SSc patients have increased production of autoreactive antibodies and …
A reactive oxygen species–mediated loop maintains increased expression of NADPH oxidases 2 and 4 in skin fibroblasts from patients with systemic sclerosis
T Spadoni, S Svegliati Baroni, D Amico… - Arthritis & …, 2015 - Wiley Online Library
Objective Reactive oxygen species (ROS) contribute to the pathogenesis of fibrosis in systemic
sclerosis (SSc; scleroderma), and NADPH oxidase (NOX) is an important source of ROS. …
sclerosis (SSc; scleroderma), and NADPH oxidase (NOX) is an important source of ROS. …
Induction of Scleroderma Fibrosis in Skin‐Humanized Mice by Administration of Anti− Platelet‐Derived Growth Factor Receptor Agonistic Autoantibodies
…, S Svegliati Baroni, T Spadoni… - Arthritis & …, 2016 - Wiley Online Library
Objective To describe a skin–SCID mouse chimeric model of systemic sclerosis (SSc;
scleroderma) fibrosis based on engraftment of ex vivo–bioengineered skin using skin cells derived …
scleroderma) fibrosis based on engraftment of ex vivo–bioengineered skin using skin cells derived …
NADPH oxidase, oxidative stress and fibrosis in systemic sclerosis
S Svegliati, T Spadoni, G Moroncini… - Free Radical Biology and …, 2018 - Elsevier
Systemic sclerosis (SSc) is an autoimmune disease characterized by damage of small vessels,
immune abnormalities and exaggerated production of extracellular matrix. The etiology …
immune abnormalities and exaggerated production of extracellular matrix. The etiology …
Gut epithelial impairment, microbial translocation and immune system activation in inflammatory bowel disease–associated spondyloarthritis
…, C Avellini, D Benfaremo, A Rizzo, T Spadoni… - …, 2021 - academic.oup.com
Objectives Gut microbiota has been widely reported to be involved in systemic inflammation
through microbial translocation and T cell activation in several diseases. In this work we …
through microbial translocation and T cell activation in several diseases. In this work we …
[HTML][HTML] Agonistic Anti-PDGF Receptor Autoantibodies from Patients with Systemic Sclerosis Impact Human Pulmonary Artery Smooth Muscle Cells Function In Vitro
S Svegliati, D Amico, T Spadoni, C Fischetti… - Frontiers in …, 2017 - frontiersin.org
One of the earliest events in the pathogenesis of systemic sclerosis (SSc) is microvasculature
damage with intimal hyperplasia and accumulation of cells expressing PDGF receptor. …
damage with intimal hyperplasia and accumulation of cells expressing PDGF receptor. …
[HTML][HTML] Metabolomic profile of systemic sclerosis patients
…, S Poddighe, M Lussu, A Manzin, T Spadoni… - Scientific Reports, 2018 - nature.com
Systemic sclerosis (SSc) is an autoimmune disease of unknown aetiology characterized by
vascular lesions, immunological alterations and diffuse fibrosis of the skin and internal organs…
vascular lesions, immunological alterations and diffuse fibrosis of the skin and internal organs…
[HTML][HTML] Intracellular free radical production by peripheral blood T lymphocytes from patients with systemic sclerosis: role of NADPH oxidase and ERK1/2
D Amico, T Spadoni, M Rovinelli, M Serafini… - Arthritis Research & …, 2015 - Springer
Introduction Abnormal oxidative stress has been described in systemic sclerosis (SSc) and
previous works from our laboratory demonstrated an increased generation of reactive oxygen …
previous works from our laboratory demonstrated an increased generation of reactive oxygen …