A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of
cellular inflammatory processes such as the induction by IFN-γ of inducible nitric oxide …

This account exemplifies our recent progress on the strategic incorporation of fluorine and
organofluorine groups to (i) taxoid anticancer agents, (ii) acylhydrazone-based antifungal …

We have synthesized more than 80 novel triterpenoids, all derivatives of oleanolic and
ursolic acid, as potential anti-inflammatory and chemopreventive agents. These triterpenoids …

The new synthetic oleanane triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO)
is a potent, multifunctional molecule. It induces monocytic differentiation of human …

We have designed and synthesized 16 new olean- and urs-1-en-3-one triterpenoids with
various modified rings C as potential antiinflammatory and cancer chemopreventive agents …

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and
its derivative 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO-Im) are …

Synthetic triterpenoids have been developed, which are potent inducers of cytoprotective
enzymes and inhibitors of inflammation, greatly improving on the weak activity of naturally …

New derivatives with electron-withdrawing substituents at the C-2 position of 3-oxoolean-1-en-28-oic
acid were synthesized. Among them, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic …

Synthetic triterpenoid analogues of oleanolic acid are potent inducers of the phase 2
response as well as inhibitors of inflammation. We show that the triterpenoid, 1-[2-cyano-3-,12-…

Background & Aims Nonalcoholic steatohepatitis (NASH) is associated with oxidative stress.
We surmised that pharmacologic activation of NF-E2 p45-related factor 2 (Nrf2) using the …