Objective Systemic sclerosis (SSc) affects both microvascular structure and function. Laser
Doppler imaging (LDI) and thermal imaging can be used to measure cutaneous blood vessel …

Objective Reliable and objective outcome measures to facilitate clinical trials of novel treatments
for systemic sclerosis ( SS c)–related Raynaud's phenomenon ( RP ) are badly needed. …

Objective. To investigate the inter- and intra-observer reliability of both qualitative and
quantitative parameters used in the assessment of nail-fold capillaroscopy images. Methods. Fifty …

Objectives. To quantify nailfold capillary density and dimensions in patients with idiopathic
inflammatory myopathy (IIM) and compare them with those in healthy controls; to look for …

Objectives. Advances in nail-fold capillaroscopy allow capillary abnormalities to be quantified.
Our aim was to investigate, in patients with SSc, the relationships between the degree of …

Objective. Few rheumatologists have access to wide field or video capillaroscopy (abnormal
capillaries being highly predictive of CTD), and a key question is whether they should, …

Background and Objectives Laser Doppler imaging (LDI) of perfusion has been performed
with a novel green wavelength (532 nm) for comparison with a HeNe laser (633 nm), the aim …

Objectives. Our primary purpose was to evaluate the efficacy of the high-potency α 2C -adrenoceptor
antagonist ORM-12741 in the attenuation of a cold-induced reduction in finger …

Extensive morphoea causes major morbidity, disability and disfigurement; pathophysiology
is poorly understood. The aim of this study was to investigate, with non-invasive imaging, the …

Objectives. Nailfold videocapillaroscopy is being increasingly used as a marker of SSc-related
microvascular disease, including in response to treatment. However, it requires further …