[HTML][HTML] HIV-1-encoded antisense RNA suppresses viral replication for a prolonged period

M Kobayashi-Ishihara, M Yamagishi, T Hara… - Retrovirology, 2012 - Springer
Background Recent evidence proposes a novel concept that mammalian natural antisense
RNAs play important roles in cellular homeostasis by regulating the expression of several …

Efficacy and limitation of infliximab treatment for children with Kawasaki disease intractable to intravenous immunoglobulin therapy: report of an open-label case …

M Mori, T Imagawa, R Hara, M Kikuchi, T Hara… - The Journal of …, 2012 - jrheum.org
Objective. Kawasaki disease (KD) is an acute febrile disease in infants and young children.
Five percent to 8% of cases will be complicated with coronary dilatation or aneurysm, …

[HTML][HTML] Infliximab versus intravenous immunoglobulin for refractory Kawasaki disease: a phase 3, randomized, open-label, active-controlled, parallel-group …

M Mori, T Hara, M Kikuchi, H Shimizu, T Miyamoto… - Scientific reports, 2018 - nature.com
We compared the efficacy and safety of infliximab with intravenous immunoglobulin (IVIG), a
standard therapy, in a phase 3 trial (NCT01596335) for Japanese patients with Kawasaki …

Influence of polymorphisms within the methotrexate pathway genes on the toxicity and efficacy of methotrexate in patients with juvenile idiopathic arthritis

…, T Naruto, T Hara, M Kikuchi, R Hara… - British journal of …, 2011 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Methotrexate (MTX), which causes
adverse effects, such as liver and/or renal dysfunction, is the most common disease‐…

Association of IRF5 polymorphisms with susceptibility to macrophage activation syndrome in patients with juvenile idiopathic arthritis

…, T Miyamae, T Hara, M Kikuchi, R Hara… - The Journal of …, 2011 - jrheum.org
Objective. Systemic-onset juvenile idiopathic arthritis (systemic JIA) and macrophage activation
syndrome (MAS), the most devastating complication of systemic JIA, are characterized …

Cranial base repair using suturing technique combined with a mucosal flap for cerebrospinal fluid leakage during endoscopic endonasal surgery

T Hara, H Akutsu, T Yamamoto, S Tanaka, S Takano… - World Neurosurgery, 2015 - Elsevier
Objective To evaluate a cranial base repair method using the dural suturing technique in
combination with a mucosal flap in the endoscopic endonasal approach. Methods We analyzed …

Human parechovirus-3 infection in nine neonates and infants presenting symptoms of hemophagocytic lymphohistiocytosis

…, F Tanaka, S Kai, K Ao, N Kikuchi, T Hara… - Journal of Infection and …, 2013 - Elsevier
Human parechovirus-3 (HPeV-3) has been reported to cause a sepsis-like illness in neonates
and young infants. We experienced the occurrence of HPeV-3 infection in nine neonates …

Infliximab for the treatment of refractory Kawasaki disease: a nationwide survey in Japan

…, T Hara, T Kanetaka, T Kizawa, M Kikuchi, R Hara… - The Journal of …, 2018 - Elsevier
Objective To assess the safety and efficacy of infliximab (IFX) for the treatment of patients
with Kawasaki disease (KD). Study design This was a nationwide survey of 274 Japanese …

[HTML][HTML] A mixed antioxidant supplement improves cognitive function, and coordination in aged mice

…, Y Kato, S Yuzawa, A Kishimoto, T Hara… - Journal of Clinical …, 2024 - ncbi.nlm.nih.gov
Accumulation of oxidative damage increases the risk of several disorders. To prevent these
diseases, people consume supplements. However, there is little evidence of the impact of …

Improvement of computational efficiency in flexible computer-aided process planning

E Morinaga, T Hara, H Joko, H Wakamatsu… - International Journal of …, 2014 - jstage.jst.go.jp
Process planning plays an important role as a bridge between product design and manufacturing.
Computer-aided process planning (CAPP) has been a topic of discussion in this half …