User profiles for TAKAHIKO HORIUCHI

Takahiko Horiuchi

Professor, Chair, Department of Imaging Sciences, Chiba University
Verified email at faculty.chiba-u.jp
Cited by 2231

Transmembrane TNF-α: structure, function and interaction with anti-TNF agents

T Horiuchi, H Mitoma, S Harashima… - …, 2010 - academic.oup.com
Transmembrane TNF-α, a precursor of the soluble form of TNF-α, is expressed on activated
macrophages and lymphocytes as well as other cell types. After processing by TNF-α-…

Mutation of DNASE1 in people with systemic lupus erythematosus

K Yasutomo, T Horiuchi, S Kagami, H Tsukamoto… - Nature …, 2001 - nature.com
Systemic lupus erythematosus (SLE) is a highly prevalent human autoimmune diseases
that causes progressive glomerulonephritis, arthritis and an erythematoid rash 1, 2. Mice …

Mechanisms for cytotoxic effects of anti–tumor necrosis factor agents on transmembrane tumor necrosis factor α–expressing cells: comparison among infliximab …

H Mitoma, T Horiuchi, H Tsukamoto… - Arthritis & …, 2008 - Wiley Online Library
Objective Three anti–tumor necrosis factor α (anti‐TNFα) agents have been proved to be
effective for rheumatoid arthritis (RA) and other inflammatory disorders. Infliximab and …

Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea

S Yoshizawa, T Horiuchi, H Fujiki… - Phytotherapy …, 1987 - Wiley Online Library
(−)‐Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of extracts of
green tea. EGCG slightly inhibited specific binding of [ 3 H] 12‐0‐tetradecanoylphorbol‐13‐…

Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus

…, M Shinozaki, H Hirakata, T Horiuchi… - … : Official Journal of …, 1999 - Wiley Online Library
Objective To analyze the Th1/Th2 balance of peripheral Th cells in patients with systemic
lupus erythematosus (SLE). Methods The Th1:Th2 ratio was analyzed in 3 groups: SLE without …

[HTML][HTML] Immunogenicity of biologics in chronic inflammatory diseases: a systematic review

…, A Balsa, J Al-Saleh, L Barile-Fabris, T Horiuchi… - BioDrugs, 2017 - Springer
Objectives A systematic review was conducted to explore the immunogenicity of biologic
agents across inflammatory diseases and its potential impact on efficacy/safety. Methods …

Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-α

H Mitoma, T Horiuchi, N Hatta, H Tsukamoto… - Gastroenterology, 2005 - Elsevier
Background & Aims: Both infliximab (chimeric anti-tumor necrosis factor [TNF]-α antibody)
and etanercept (p75 TNF-α receptor/immunoglobulin G fusion protein) are effective against …

C5a induces tissue factor activity on endothelial cells

K Ikeda, K Nagasawa, T Horiuchi… - Thrombosis and …, 1997 - thieme-connect.com
Tissue factor (TF) is an integral membrane glycoprotein that serves as a cofactor for blood
coagulation factor VIIa. The induction of TF on the surface of endothelial cells is initiated by …

Molecular mechanisms of action of anti-TNF-α agents–Comparison among therapeutic TNF-α antagonists

H Mitoma, T Horiuchi, H Tsukamoto, N Ueda - Cytokine, 2018 - Elsevier
Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in
inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti-TNF-…

Genetic variations of Toll-like receptor 9 predispose to systemic lupus erythematosus in Japanese population

…, K Kishihara, Y Kimoto, T Horiuchi… - Annals of the …, 2007 - ard.bmj.com
Background: Systemic lupus erythematosus (SLE) is characterised by dysregulation of
autoreactive lymphocytes and antigen-presenting cells. Signalling through Toll-like receptor 9 (…