Diabetic nephropathy is a serious complication of diabetes mellitus, and its prevalence has
been increasing worldwide. Therefore, there is an urgent need to identify a new therapeutic …

… Continuous variables were compared by means of Student's t test. Event rates were
calculated as the ratio of observed events per total number of patient-years of exposure. The first …

Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies
demonstrate that this process is attenuated by calorie restriction (CR). However, the molecular …

Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. The
multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and …

… Determinations of the significance of differences in the sodium-sensitivity index, age, sex
distribution, body mass index, and U Na V were made by Student’s t test for paired and …

… C t value was used to compute the levels of mRNA expression from the standard curve.
Analytical data were adjusted with the levels of mRNA expression of β-actin as an internal control…

Background—Recently, we found that sodium restriction shifted the circadian rhythm of
blood pressure from nondipper to dipper in patients with the sodium-sensitive essential …

… C t values were used to compute the levels of mRNA expression from the standard curve.
Analytical data were adjusted with the levels of mRNA expression of β-actin as an internal …

SIRT1, a class III histone deacetylase, is considered a key regulator of cell survival and
apoptosis through its interaction with nuclear proteins. In this study, we have examined the …

Diabetic nephropathy is the leading cause of end-stage renal disease worldwide. The
multipronged drug approach still fails to fully prevent the onset and progression of diabetic …