Functional Dynamics of Deuterated β2‐Adrenergic Receptor in Lipid Bilayers Revealed by NMR Spectroscopy
…, J Okude, Y Shiraishi, K Kondo, T Mizumura… - Angewandte …, 2014 - Wiley Online Library
G‐protein‐coupled receptors (GPCRs) exist in conformational equilibrium between active
and inactive states, and the former population determines the efficacy of signaling. However, …
and inactive states, and the former population determines the efficacy of signaling. However, …
Identification of a conformational equilibrium that determines the efficacy and functional selectivity of the μ‐opioid receptor
…, K Kondo, Y Shiraishi, T Mizumura… - Angewandte Chemie …, 2015 - Wiley Online Library
G‐protein‐coupled receptor (GPCR) ligands impart differing degrees of signaling in the G‐protein
and arrestin pathways, in phenomena called “biased signaling”. However, the …
and arrestin pathways, in phenomena called “biased signaling”. However, the …
Novel ELISA for the detection of raw and processed egg using extraction buffer containing a surfactant and a reducing agent
Y Watanabe, K Aburatani, T Mizumura, M Sakai… - Journal of …, 2005 - Elsevier
Enzyme-linked immunosorbent assay (ELISA) has been considered extremely useful for the
detection of markers of allergenic substances in food, because it is simple, offers a suitable …
detection of markers of allergenic substances in food, because it is simple, offers a suitable …
A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion
RJ Gumina, T Mizumura, N Beier, P Schelling… - … of Pharmacology and …, 1998 - ASPET
Administration of inhibitors of the Na + /H + exchanger (NHE) have been shown to produce
cardioprotective effects in a number of animal models of ischemia-reperfusion injury; however…
cardioprotective effects in a number of animal models of ischemia-reperfusion injury; however…
Activation of adenosine A2A receptor by lipids from docosahexaenoic acid revealed by NMR
T Mizumura, K Kondo, M Kurita, Y Kofuku… - Science …, 2020 - science.org
The lipid composition of the plasma membrane is a key parameter in controlling signal
transduction through G protein–coupled receptors (GPCRs). Adenosine A 2A receptor (A 2A AR) …
transduction through G protein–coupled receptors (GPCRs). Adenosine A 2A receptor (A 2A AR) …
Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil …
T Mizumura, K Nithipatikom, GJ Gross - Circulation, 1995 - Am Heart Assoc
Background The primary goal of the present study was to determine whether the infarct size–reducing
effect of preconditioning is associated with an increase in adenosine release from …
effect of preconditioning is associated with an increase in adenosine release from …
PD 81,723, an Allosteric Enhancer of the A1 Adenosine Receptor, Lowers the Threshold for Ischemic Preconditioning in Dogs
T Mizumura, JA Auchampach, J Linden… - Circulation …, 1996 - Am Heart Assoc
… PD enhanced the binding of [ 125 I]N 6 -4-amino-3-iodobenzyladenosine ( 125 I-ABA) to
A 1 receptors by increasing the t 1/2 for dissociation by 2.18-fold, but PD had no effect on the …
A 1 receptors by increasing the t 1/2 for dissociation by 2.18-fold, but PD had no effect on the …
Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog
T Mizumura, K Nithipatikom… - Cardiovascular research, 1995 - academic.oup.com
Objective: The major aim of this study was to determine if nicorandil, a potassium channel
opener nitrate, produces a reduction in myocardial infarct size at a non-hypotensive dose in …
opener nitrate, produces a reduction in myocardial infarct size at a non-hypotensive dose in …
Conductivity study on ionic liquid/polymer complexes
M Watanabe, T Mizumura - Solid State Ionics, 1996 - Elsevier
… T, of the mixtures are 55C and 52C respectively, and T,‘s are well below room temperature.
The quenched sahs are found to form stable supercooled liquids at room temperature for at …
The quenched sahs are found to form stable supercooled liquids at room temperature for at …
Regulation of intracellular formaldehyde toxicity during methanol metabolism of the methylotrophic yeast Pichia methanolica
…, S Yamaguchi, A Takeuchi, T Mizumura… - Journal of bioscience …, 2016 - Elsevier
In this study we found that the methylotrophic yeast Pichia methanolica showed impaired
growth on high methanol medium (>5%, or 1.56 M, methanol). In contrast, P. methanolica grew …
growth on high methanol medium (>5%, or 1.56 M, methanol). In contrast, P. methanolica grew …