Functional Dynamics of Deuterated β2‐Adrenergic Receptor in Lipid Bilayers Revealed by NMR Spectroscopy

…, J Okude, Y Shiraishi, K Kondo, T Mizumura… - Angewandte …, 2014 - Wiley Online Library
G‐protein‐coupled receptors (GPCRs) exist in conformational equilibrium between active
and inactive states, and the former population determines the efficacy of signaling. However, …

Identification of a conformational equilibrium that determines the efficacy and functional selectivity of the μ‐opioid receptor

…, K Kondo, Y Shiraishi, T Mizumura… - Angewandte Chemie …, 2015 - Wiley Online Library
G‐protein‐coupled receptor (GPCR) ligands impart differing degrees of signaling in the G‐protein
and arrestin pathways, in phenomena called “biased signaling”. However, the …

Novel ELISA for the detection of raw and processed egg using extraction buffer containing a surfactant and a reducing agent

Y Watanabe, K Aburatani, T Mizumura, M Sakai… - Journal of …, 2005 - Elsevier
Enzyme-linked immunosorbent assay (ELISA) has been considered extremely useful for the
detection of markers of allergenic substances in food, because it is simple, offers a suitable …

A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion

RJ Gumina, T Mizumura, N Beier, P Schelling… - … of Pharmacology and …, 1998 - ASPET
Administration of inhibitors of the Na + /H + exchanger (NHE) have been shown to produce
cardioprotective effects in a number of animal models of ischemia-reperfusion injury; however…

Activation of adenosine A2A receptor by lipids from docosahexaenoic acid revealed by NMR

T Mizumura, K Kondo, M Kurita, Y Kofuku… - Science …, 2020 - science.org
The lipid composition of the plasma membrane is a key parameter in controlling signal
transduction through G protein–coupled receptors (GPCRs). Adenosine A 2A receptor (A 2A AR) …

Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil …

T Mizumura, K Nithipatikom, GJ Gross - Circulation, 1995 - Am Heart Assoc
Background The primary goal of the present study was to determine whether the infarct size–reducing
effect of preconditioning is associated with an increase in adenosine release from …

PD 81,723, an Allosteric Enhancer of the A1 Adenosine Receptor, Lowers the Threshold for Ischemic Preconditioning in Dogs

T Mizumura, JA Auchampach, J Linden… - Circulation …, 1996 - Am Heart Assoc
… PD enhanced the binding of [ 125 I]N 6 -4-amino-3-iodobenzyladenosine ( 125 I-ABA) to
A 1 receptors by increasing the t 1/2 for dissociation by 2.18-fold, but PD had no effect on the …

Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog

T Mizumura, K Nithipatikom… - Cardiovascular research, 1995 - academic.oup.com
Objective: The major aim of this study was to determine if nicorandil, a potassium channel
opener nitrate, produces a reduction in myocardial infarct size at a non-hypotensive dose in …

Conductivity study on ionic liquid/polymer complexes

M Watanabe, T Mizumura - Solid State Ionics, 1996 - Elsevier
T, of the mixtures are 55C and 52C respectively, and T,‘s are well below room temperature.
The quenched sahs are found to form stable supercooled liquids at room temperature for at …

Regulation of intracellular formaldehyde toxicity during methanol metabolism of the methylotrophic yeast Pichia methanolica

…, S Yamaguchi, A Takeuchi, T Mizumura… - Journal of bioscience …, 2016 - Elsevier
In this study we found that the methylotrophic yeast Pichia methanolica showed impaired
growth on high methanol medium (>5%, or 1.56 M, methanol). In contrast, P. methanolica grew …