Background Systemic-onset juvenile idiopathic arthritis does not always respond to available
treatments, including antitumour necrosis factor agents. We investigated the efficacy and …

Objective To investigate the safety and efficacy of a recombinant human anti–interleukin‐6 (anti–IL‐6)
receptor monoclonal antibody (MRA) that indirectly inhibits the effects of IL‐6 in …

… Both CD4 + T and CD8 + T cells were decreased in the pancreas and peripheral lymph
nodes. In the bone marrow, pancytopenia was observed. Degeneration and necrosis of …

Historically, 3,4-dihydroxyphenylalanine (DOPA) has been considered to be an inert amino
acid that alleviates the symptoms of Parkinson's disease by its conversion to dopamine via …

Background: It has long been assumed that the development of childhood asthma is related
to exposure to environmental chemicals, but it has thus far not been possible to …

The electrochemical interface between a polycrystalline Pt electrode and the ionic liquid 1-butyl-3-methylimidazolium
trifluoromethanesulfonate ([bmim][OTf]) has been studied by in-situ …

While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly
characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws …

… Shown above each graph are the t statistics and p values from Student's t tests for each
variable. Q–Q plots and Shapiro–Wilk analyses revealed a deviation from normality for AP half-…

… Astrocytes also synthesize TNF-α and IL-6, express B7 costimulatory molecules and
prime the naive antigen-specific T cells. Thus, the glial cells mimic macrophages in cytokine …

… The higher-than-predicted molecular weight for mMFG-E8-L is probably owing to the
additional EGF and P/T domains and to the presence of two additional N-glycosylation sites. …