Context There are few randomized controlled trials on the effectiveness of palliative care
interventions to improve the care of patients with advanced cancer. Objective To determine the …

Background Surgery for spinal stenosis is widely performed, but its effectiveness as compared
with nonsurgical treatment has not been shown in controlled trials. Methods Surgical …

ContextLumbar diskectomy is the most common surgical procedure performed for back and
leg symptoms in US patients, but the efficacy of the procedure relative to nonoperative care …

Background Pathogenic variants of the DPYD gene are strongly associated with grade ≥3
toxicity during fluoropyrimidine chemotherapy. We conducted a systematic review and meta-…

Purpose Randomized controlled trials have supported integrated oncology and palliative
care (PC); however, optimal timing has not been evaluated. We investigated the effect of early …

Background Management of degenerative spondylolisthesis with spinal stenosis is
controversial. Surgery is widely used, but its effectiveness in comparison with that of nonsurgical …

ContextFor patients with lumbar disk herniation, the Spine Patient Outcomes Research Trial
(SPORT) randomized trial intent-to-treat analysis showed small but not statistically …

… Cummins J, Lurie JD, Tosteson TD, et al. Descriptive epidemiology and prior healthcare
utilization of patients in The Spine Patient Outcomes Research Trial's (SPORT) three …

Background People who consume a diet high in vegetables and fruits have a lower risk of
cancer of the large bowel. Antioxidant vitamins, which are present in vegetables and fruits, …

A hospital-based survey on shift work, sleep, and accidents was carried out among 635
Massachusetts nurses. In comparison to nurses who worked only day/evening shifts, rotators …