OBJECTIVE To investigate the incidence of retinopathy in systemic lupus erythematosus (SLE)
and to clarify its significance in relation to other clinical manifestations. METHODS A …

At least 20 insulin-dependent diabetes (Idd) loci modify the progression of autoimmune
diabetes in the NOD mouse, an animal model of human type 1 diabetes. The NOD. c3c4 …

Objective Interferon regulatory factor 5 (IRF‐5) is a transcription factor that mediates intracellular
signals activated by engagement of Toll‐like receptors (TLRs). IRF5 polymorphisms are …

This study aimed to investigate phenotype of RP105(−) B cell subsets in patients with systemic
lupus erythematosus (SLE). Flow cytometry was used for phenotyping RP105-negaive B …

Objective The efficacy of biologics in treating adult Still’s disease (ASD) is suggested, but
the information is still lacking and the validation is insufficient. To determine the efficacy of …

OBJECTIVE: To examine the frequency of depressive symptoms and also to identify factors
closely associated with their development in patients with scleroderma (systemic sclerosis, …

Objectives To clarify the characteristics of patients with elderly-onset Adult-onset Still’s disease
(AOSD). Methods Patients were classified into elderly-onset (>60 years: 47 patients) and …

Objective Based on the antibody profiles of inflammatory myositis patients, we investigated
the type 1 IFN (T1-IFN) signature in serum and DM skin to determine the relationship …

Objective RP105 is a leucine‐rich repeat (LRR) protein found on all mature mouse B cells.
Its function is poorly defined, although it has been suggested that RP105 activates B cells to …

MRL/Mpj-lpr/lpr (MRL/lpr) mice develop autoimmune disorders, including lymphoproliferation,
glomerulonephritis, autoantibody production, and hypergammaglobulinemia. To …