Background: Although mass screening for osteoporosis is not recommended among
postmenopausal women, there is no consensus on which women should undergo testing for low …

Patients who adhere to preventive therapies may be more likely to engage in a broad spectrum
of behaviors consistent with a healthy lifestyle. Because many of these behaviors cannot …

Objectives To describe the use and reporting of interrupted time series methods in drug
utilization research. Study Design and Setting We completed a systematic search of MEDLINE, …

Knowing a person’s fracture risk according to their kidney function, gender, and age may
influence clinical management and decision-making. Using healthcare databases from Ontario, …

Background Many patients who initiate statin (3-hydroxy-3-methylglutaryl coenzyme A reductase
inhibitor) therapy discontinue treatment within 1 year. We sought to estimate the rate at …

ContextIdentification of women with low bone mineral density (BMD) is an important strategy
in reducing the incidence of osteoporotic fractures. However, screening all women is not …

Health care administrative data are generated at every encounter with the health care system,
whether through a visit to a physician’s office, a diagnostic procedure, an admission to …

Background: Insurers and policymakers strive to stimulate more cost-effective prescribing
and, increasingly, are educating beneficiaries about generics. Objectives: To evaluate the …

Objectives: WithClostridium difficileinfection (CDI) on the rise, knowledge of the current
economic burden of CDI can inform decisions on interventions related to CDI. We systematically …

Purpose Consensus is needed on conceptual foundations, terminology and relationships
among the various self‐controlled “trigger” study designs that control for time‐invariant …