CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…

… Goodman and Springer contributed equally to this work. Drs. Singh and Yates contributed …
Goodman had full access to all of the data in the study and takes responsibility for the integrity …

Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate
tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation …

Droplet-based single-cell RNA-seq has emerged as a powerful technique for massively parallel
cellular profiling. While this approach offers the exciting promise to deconvolute cellular …

Inflammation of non-barrier immunologically quiescent tissues is associated with a massive
influx of blood-borne innate and adaptive immune cells. Cues from the latter are likely to …

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction 1 . There is currently no cure for rheumatoid arthritis, and the effectiveness of …

Objective To develop initial American College of Rheumatology (ACR) guidelines on the
use of exercise, rehabilitation, diet, and additional interventions in conjunction with disease‐…

Objective In this study, we sought to refine histologic scoring of rheumatoid arthritis ( RA )
synovial tissue by training with gene expression data and machine learning. Methods Twenty …

Macrophages tailor their function according to the signals found in tissue microenvironments,
assuming a wide spectrum of phenotypes. A detailed understanding of macrophage …