Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to
prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit …

10.7554/eLife.01202.001 Rheumatoid arthritis (RA) is a prevalent systemic autoimmune
disease, caused by a combination of genetic and environmental factors. Animal models suggest …

Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of
the most common diseases among mammals. Although this musculoskeletal disorder has …

Prostaglandin E 2 (PGE 2 ) is a principal mediator of inflammation in diseases such as
rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs) and …

Objective To characterize the diversity and taxonomic relative abundance of the gut
microbiota in patients with never‐treated, recent‐onset psoriatic arthritis (PsA). Methods High‐…

The growth factor progranulin (PGRN) has been implicated in embryonic development, tissue
repair, tumorigenesis, and inflammation, but its receptors remain unidentified. We report …

Tetracyclines have recently been shown to have “chondroprotective” effects in inflammatory
arthritides in animal models. Since nitric oxide (NO) is spontaneously released from human …

Osteoarthritis is often a progressive and disabling disease, which occurs in the setting of a
variety of risk factors – such as advancing age, obesity, and trauma – that conspire to incite a …

Objective: Nitric oxide, a potent vasodilator released by endothelial cells, inhibits platelet
aggregation and adhesion to vascular endothelial surfaces. Because endothelial cell damage …

… B, The prevalence of P gingivalis in the oral microbiota was determined by 16S ribosomal
RNA … Abramson had full access to all of the data in the study and takes responsibility for the …