[PDF][PDF] Genome-wide ancestry patterns in Rapanui suggest pre-European admixture with Native Americans
Background Rapa Nui (Easter Island), located in the easternmost corner of the Polynesian
Triangle, is one of the most isolated locations on the planet inhabited by humans. …
Triangle, is one of the most isolated locations on the planet inhabited by humans. …
[HTML][HTML] Multimodal human thymic profiling reveals trajectories and cellular milieu for T agonist selection
M Heimli, ST Flåm, HS Hjorthaug, D Trinh… - Frontiers in …, 2023 - frontiersin.org
To prevent autoimmunity, thymocytes expressing self-reactive T cell receptors (TCRs) are
negatively selected, however, divergence into tolerogenic, agonist selected lineages represent …
negatively selected, however, divergence into tolerogenic, agonist selected lineages represent …
The HLA profiles of mixed connective tissue disease differ distinctly from the profiles of clinically related connective tissue diseases
ST Flåm, R Gunnarsson, T Garen… - …, 2015 - academic.oup.com
Objective. The Norwegian nationwide MCTD cohort was established to obtain unbiased data
on key disease issues, and thereby reappraise the concept of MCTD. In the current study, …
on key disease issues, and thereby reappraise the concept of MCTD. In the current study, …
[HTML][HTML] Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement
MD Vigeland, ST Flåm, MD Vigeland, A Espeland… - Scientific reports, 2022 - nature.com
Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical
explanations cause huge problems both for patients and society. A subgroup of patients …
explanations cause huge problems both for patients and society. A subgroup of patients …
Genetic risk variants for autoimmune diseases that influence gene expression in thymus
…, SS Amundsen, H Helgeland, ST Flåm… - Human molecular …, 2016 - academic.oup.com
Genome-wide association studies (GWAS) have boosted our knowledge of genetic risk variants
in autoimmune diseases (AIDs). Most risk variants are located within or near genes with …
in autoimmune diseases (AIDs). Most risk variants are located within or near genes with …
[HTML][HTML] Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq
M Heimli, S Tennebø Flåm, H Sagsveen Hjorthaug… - Scientific Reports, 2023 - nature.com
Thymic T cell development comprises T cell receptor (TCR) recombination and assessment
of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells. …
of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells. …
[HTML][HTML] Transcriptome profiling of human thymic CD4+ and CD8+ T cells compared to primary peripheral T cells
…, I Gabrielsen, H Akselsen, AYM Sundaram, ST Flåm… - BMC genomics, 2020 - Springer
Background The thymus is a highly specialized organ of the immune system where T cell
precursors develop and differentiate into self-tolerant CD4+ or CD8+ T cells. No studies to date …
precursors develop and differentiate into self-tolerant CD4+ or CD8+ T cells. No studies to date …
[PDF][PDF] The HLA profiles of mixed connective tissue disease differ distinctly from the profiles of clinically related connective tissue diseases
ST Flam, R Gunnarsson, T Garen, BA Lie… - Rheumatology (Oxford …, 2015 - Citeseer
Objective. The Norwegian nationwide MCTD cohort was established to obtain unbiased data
on key disease issues, and thereby reappraise the concept of MCTD. In the current study, …
on key disease issues, and thereby reappraise the concept of MCTD. In the current study, …
Lack of association among peptidyl arginine deiminase type 4 autoantibodies, PADI4 polymorphisms, and clinical characteristics in rheumatoid arthritis
…, BK Andreassen, Ø Molberg, ST Flåm… - The Journal of …, 2018 - jrheum.org
Objective. We aimed to jointly investigate the role of antipeptidyl arginine deiminase type 4
antibodies (anti-PAD4) and polymorphisms in the PADI4 gene together with clinical variables …
antibodies (anti-PAD4) and polymorphisms in the PADI4 gene together with clinical variables …
[HTML][HTML] Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes
MD Vigeland, ST Flåm, MD Vigeland, A Espeland… - Antibiotics, 2023 - mdpi.com
Long-term antibiotics are prescribed for a variety of medical conditions, recently including
low back pain with Modic changes. The molecular impact of such treatment is unknown. We …
low back pain with Modic changes. The molecular impact of such treatment is unknown. We …