Objective Neonatal‐onset multisystem inflammatory disease (NOMID; also known as chronic
infantile neurologic, cutaneous, articular [CINCA] syndrome) is characterized by fever, …

Interferons (IFNs) are essential for host defense. Although the antiviral effects of the type 1
IFNs IFN-α and IFN-β (IFN-α/β) have been established, their immunoregulatory functions, …

Purpose of Review Chronic non-bacterial osteomyelitis (CNO) with its most severe form
chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder. We …

Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including
chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal …

The recent elucidation of the multiple molecular mechanisms underlying severe combined
immunodeficiency (SCID) is an impressive example of the power of molecular medicine. …

The discovery that Jak3 mutations are a significant cause of severe combined immunodeficiency
(SCID), a rare inherited defect characterized by lymphopenia, has provided valuable …

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disorder of
unknown origin. We previously demonstrated that monocytes from CRMO patients fail to …

Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder, covering a
clinical spectrum with asymptomatic inflammation of single bones at the one end, and …

New cytokines and receptors continue to be identified. The discovery and characterization
of cytokines, their receptors and signaling molecules will provide a more complete …

Background Monogenic autoinflammatory disorders are characterized by dysregulation of
the innate immune system, for example by gain-of-function mutations in inflammasome-…