Background Systemic-onset juvenile idiopathic arthritis does not always respond to available
treatments, including antitumour necrosis factor agents. We investigated the efficacy and …

Objective To investigate the safety and efficacy of a recombinant human anti–interleukin‐6 (anti–IL‐6)
receptor monoclonal antibody (MRA) that indirectly inhibits the effects of IL‐6 in …

Since the initial report of unusual manifestations possibly associated with chronic active
Epstein‐Barr virus (EBV) infection (CAEBV), nearly three decades have passed. During this …

Objective To investigate the efficacy and safety of the interleukin-6 receptor antibody tocilizumab
in patients with Takayasu arteritis (TAK). Methods Patients with TAK who had relapsed …

Chronic active Epstein-Barr virus infection (CAEBV) is a high-mortality and high-morbidity
disease. To clarify the prognostic factors, a national survey was performed in Japan, and data …

PGE, a potent vasodilator, plays a primary role in maintaining the patency of the ductus
arteriosus (DA). Genetic disruption of the PGE-specific receptor EP4, however, paradoxically …

Background: Food-dependent, exercise-induced anaphylaxis (FEIAn) is classified among the
physical allergies. The pathophysiology of FEIAn remains unknown, as does the frequency …

Objective. Rapidly progressive interstitial lung disease (RP-ILD) is a rare but potentially fatal
complication of JDM. The aim of this study was to establish markers for the prediction and …

Objective: We evaluated the efficacy of intravenous γ-globulin (IVGG) administration for
children with Kawasaki disease to establish whether additional, more advanced therapy is …

Objectives To evaluate the safety and effectiveness of tocilizumab (TCZ) in patients with
systemic juvenile idiopathic arthritis (sJIA) in real-world clinical settings in Japan. Methods …