Hepatic fibrosis and cirrhosis: the (myo) fibroblastic cell subpopulations involved

C Guyot, S Lepreux, C Combe, E Doudnikoff… - The international journal …, 2006 - Elsevier
Fibrosis, defined as the excessive deposition of extracellular matrix in an organ, is the main
complication of chronic liver damage. Its endpoint is cirrhosis, which is responsible for …

Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss

…, JY Scoazec, T Bachelet, S Lepreux… - Journal of the …, 2015 - journals.lww.com
Antibody-mediated rejection (AMR) is a major cause of kidney graft loss, yet assessment of
individual risk at diagnosis is impeded by the lack of a reliable prognosis assay. Here, we …

[HTML][HTML] Blood platelets and sepsis pathophysiology: a new therapeutic prospect in critical ill patients?

A Dewitte, S Lepreux, J Villeneuve, C Rigothier… - Annals of intensive …, 2017 - Springer
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Non-complement–binding de novo donor-specific anti-HLA antibodies and kidney allograft survival

G Guidicelli, F Guerville, S Lepreux… - Journal of the …, 2016 - journals.lww.com
C1q-binding ability may indicate the clinical relevance of de novo donor-specific anti-HLA
antibodies (DSA). This study investigated the incidence and risk factors for the appearance of …

[HTML][HTML] Human liver myofibroblasts during development and diseases with a focus on portal (myo) fibroblasts

S Lepreux, A Desmoulière - Frontiers in physiology, 2015 - frontiersin.org
Myofibroblasts are stromal cells mainly involved in tissue repair. These cells present contractile
properties and play a major role in extracellular matrix deposition and remodeling. In liver…

Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells

…, S Cordi, A Antoniou, P Raynaud, S Lepreux… - Gastroenterology, 2011 - Elsevier
BACKGROUND& AIMS: Embryonic biliary precursor cells form a periportal sheet called the
ductal plate, which is progressively remodeled to generate intrahepatic bile ducts. A limited …

Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis

…, A Monvoisin, C Mazzocco, S Lepreux… - The American journal of …, 2006 - Elsevier
Matrix metalloproteinase (MMP)-3 is a protease involved in cancer progression and tissue
remodeling. Using immunofluorescence and immunoelectron microscopy, we identified …

Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver

…, S Rebouissou, AS Cunha, E Jeannot, S Lepreux… - Gastroenterology, 2005 - Elsevier
Background & Aims: Telangiectatic focal nodular hyperplasia (TFNH) of the liver is generally
believed to belong to the focal nodular hyperplasia (FNH) family. The aim of this study was …

Quantitative elastography of renal transplants using supersonic shear imaging: a pilot study

N Grenier, S Poulain, S Lepreux, JL Gennisson… - European …, 2012 - Springer
Purpose To evaluate the reliability of quantitative ultrasonic measurement of renal allograft
elasticity using supersonic shear imaging (SSI) and its relationship with parenchymal …

[HTML][HTML] Altered E-cadherin levels and distribution in melanocytes precede clinical manifestations of vitiligo

…, V Petit, L Benzekri, K Ezzedine, S Lepreux… - Journal of investigative …, 2015 - Elsevier
Vitiligo is the most common depigmenting disorder resulting from the loss of melanocytes
from the basal epidermal layer. The pathogenesis of the disease is likely multifactorial and …