Decision makers in health care are increasingly interested in using high-quality scientific
evidence to support clinical and health policy choices; however, the quality of available …

CLINICAL SCENARIO You are relieved to find that the last patient in your busy primary care
clinic is a previously well 48-year-old woman with acute dysuria. There has been no …

Objective: To assess internists' familiarity with, confidence in, and attitudes about practice
guidelines issued by various organizations. Design: Cross-sectional, self-administered survey. …

Aims: Stakeholder engagement is fundamental to comparative effectiveness research (CER),
but lacks consistent terminology. This paper aims to define stakeholder engagement and …

CLINICAL SCENARIO At the conclusion of our first article on practice guidelines 1 in this
series, we left you examining the full text of a practice guideline 2 that could help you marshal a …

Background: Internationally, many health care interventions were diffused prior to the standard
use of assessments of safety, effectiveness and cost-effectiveness. Disinvestment from …

Doctors, patients, and other decision makers need access to the best available clinical
evidence, which can come from systematic reviews, experimental trials, and observational …

Background. Percutaneous transluminal angioplasty has been adopted widely as a treatment
for patients with peripheral vascular disease of the lower extremities. However, the effect of …

The NEW ENGLAND JOURNAL of MEDICINE may 7, 2009 n engl j med 360; 19 nejm. org
may 7, 2009 1925 relative effectiveness of different medical interventions is needed to …

In April 2005 the Centers for Medicare and Medicaid Services (CMS) posted on its Web site
a draft guidance document describing a new approach to coverage policy called “coverage …