Pharmacological and therapeutic effects of A3 adenosine receptor agonists
P Fishman, S Bar-Yehuda, BT Liang, KA Jacobson - Drug discovery today, 2012 - Elsevier
The A 3 adenosine receptor (A 3 AR) coupled to G i (inhibitory regulative guanine nucleotide-binding
protein) mediates anti-inflammatory, anticancer and anti-ischemic protective effects…
protein) mediates anti-inflammatory, anticancer and anti-ischemic protective effects…
The A3 Adenosine Receptor Is Highly Expressed in Tumor versus Normal Cells: Potential Target for Tumor Growth Inhibition
L Madi, A Ochaion, L Rath-Wolfson, S Bar-Yehuda… - Clinical Cancer …, 2004 - AACR
Purpose: A 3 adenosine receptor (A 3 AR) activation was shown to inhibit the growth of
various tumor cells via the down-regulation of nuclear factor κB and cyclin D1. To additionally …
various tumor cells via the down-regulation of nuclear factor κB and cyclin D1. To additionally …
A3 adenosine receptor as a target for cancer therapy
P Fishman, S Bar-Yehuda, L Madi, I Cohn - Anti-cancer drugs, 2002 - journals.lww.com
Targeting the A3 adenosine receptor (A3AR) by adenosine or a synthetic agonist to this
receptor (IB-MECA and Cl-IB-MECA) results in a differential effect on tumor and on normal cells. …
receptor (IB-MECA and Cl-IB-MECA) results in a differential effect on tumor and on normal cells. …
Differential effect of adenosine on tumor and normal cell growth: focus on the A3 adenosine receptor
G Ohana, S Bar‐Yehuda, F Barer… - Journal of cellular …, 2001 - Wiley Online Library
Adenosine is an ubiquitous nucleoside present in all body cells. It is released from metabolically
active or stressed cells and subsequently acts as a regulatory molecule through binding …
active or stressed cells and subsequently acts as a regulatory molecule through binding …
Clinical evidence for utilization of the A3 adenosine receptor as a target to treat rheumatoid arthritis: data from a phase II clinical trial.
MH Silverman, V Strand, D Markovits, M Nahir… - The Journal of …, 2008 - jrheum.org
OBJECTIVE: Adenosine exerts antiinflammatory effects via activation of the A3 adenosine
receptor (A3AR), a Gi protein-associated cell-surface receptor, overexpressed in synovial …
receptor (A3AR), a Gi protein-associated cell-surface receptor, overexpressed in synovial …
The A3 adenosine receptor as a new target for cancer therapy and chemoprotection
P Fishman, S Bar-Yehuda, F Barer, L Madi… - Experimental cell …, 2001 - Elsevier
Adenosine, a purine nucleoside, acts as a regulatory molecule, by binding to specific G-protein-coupled
A 1 , A 2A , A 2B , and A 3 cell surface receptors. We have recently …
A 1 , A 2A , A 2B , and A 3 cell surface receptors. We have recently …
[HTML][HTML] A3 adenosine receptor activation in melanoma cells: association between receptor fate and tumor growth inhibition
L Madi, S Bar-Yehuda, F Barer, E Ardon… - Journal of Biological …, 2003 - ASBMB
Activation of the G i protein-coupled A3 adenosine receptor (A3AR) has been implicated in
the inhibition of melanoma cell growth by deregulating protein kinase A and key components …
the inhibition of melanoma cell growth by deregulating protein kinase A and key components …
CF102 for the treatment of hepatocellular carcinoma: a phase I/II, open‐label, dose‐escalation study
…, NB Ciuraru, MH Silverman, S Bar‐Yehuda… - The …, 2013 - academic.oup.com
Background. The A 3 adenosine receptor (A 3 AR) is overexpressed in the tumor and in the
peripheral blood mononuclear cells of patients with hepatocellular carcinoma (HCC). The …
peripheral blood mononuclear cells of patients with hepatocellular carcinoma (HCC). The …
[HTML][HTML] The PI3K–NF-κB signal transduction pathway is involved in mediating the anti-inflammatory effect of IB-MECA in adjuvant-induced arthritis
P Fishman, S Bar-Yehuda, L Madi… - Arthritis research & …, 2006 - Springer
The anti-inflammatory effect of adenosine was previously found to be mediated via activation
of the A 3 adenosine receptor (A 3 AR). The aim of the present study was to decipher the …
of the A 3 adenosine receptor (A 3 AR). The aim of the present study was to decipher the …
[PDF][PDF] Targeting the A3 adenosine receptor for cancer therapy: inhibition of prostate carcinoma cell growth by A3AR agonist
P Fishman, S Bar-Yehuda, E Ardon… - Anticancer …, 2003 - canfite.com
Background: Agonists to A3 adenosine receptor (A3AR) were shown to inhibit the growth of
various tumor cell types. The present study demonstrates that a synthetic A3AR agonist, 1-…
various tumor cell types. The present study demonstrates that a synthetic A3AR agonist, 1-…