Adipocytes secrete a variety of bioactive molecules that affect the insulin sensitivity of other
tissues. We now show that the abundance of monocyte chemoattractant protein–1 (MCP-1) …

Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common
intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced …

MATERIALS AND METHODS Cell culture. Human bone marrow mesenchymal stem cells (hMSC)
were purchased from Poietics company. The hMSCs were expanded in MSCGM …

Mutational activation of the ras proto-oncogenes is frequently found in skin cancers. However,
the nature of downstream signaling pathways from Ras involved in skin carcinogenesis …

F10 and BL6 sublines of B16 mouse melanoma cells are metastatic after intravenous injection,
but only BL6 cells are metastatic after subcutaneous injection. We found that connexin (…

Association of decreased calcium-sensing receptor expression with proliferation of parathyroid
cells in secondary hyperparathyroidism. Background The down-regulation of both calcium…

Receptor activator of NF-κ B ligand (RANKL)/tumor necrosis factor-related activation induced
cytokine (TRANCE)/osteoprotegerin ligand (OPGL)/osteoclast differentiation factor (ODF) is …

OBJECTIVE: Programmed death-1 (PD-1) mediates a negative signal and introduces
tolerance for lymphocytes. Dysfunction of the PD-1 pathway is thought to result in autoimmune …

Background. The bcl‐2 protein has been shown to suppress apoptosis, and overexpression
of the bcl‐2 protein has been reported in several malignant tumors. Skin is one of the largest …

1α,25(OH) 2 D 3 rapidly and transiently suppressed OPG gene expression both by accelerating
the degradation of mRNA and by suppressing promoter activity. The latter process was …