[HTML][HTML] Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice

S Toyama, N Tamura, K Haruta, T Karakida… - Arthritis research & …, 2010 - Springer
Introduction Targeting joint destruction induced by osteoclasts (OCs) is critical for management
of patients with rheumatoid arthritis (RA). Since phosphoinositide 3-kinase (PI3-K) plays …

Autofeedback from ultrasound images provides rapid improvement in palpation skills for identifying joint swelling in rheumatoid arthritis

…, T Nemoto, M Kageyama, S Toyama… - The Journal of …, 2012 - jrheum.org
Objective. Joint swelling, an important factor in the classification criteria and disease activity
assessment in rheumatoid arthritis (RA), renders joint palpation a necessary skill for …

Modification of ligands for serum albumin on polyethyleneimine to stabilize polyplexes in gene delivery

…, T Nobori, H Matsumoto, S Toyama… - Journal of …, 2017 - Taylor & Francis
In this work, we have developed a new technique to stabilize a ternary complex composed
of plasmid DNA, a linear polyethyleneimine (LPEI) and serum albumin. A stearoyl group was …

Single-center, retrospective analysis of efficacy and safety of tacrolimus as a second-line DMARD in combination therapy and the risk factors contributing to adverse …

…, M Kageyama, S Onuma, M Kusaoi, S Toyama… - Clinical …, 2012 - Springer
To retrospectively evaluate the efficacy and safety of combination therapy with tacrolimus (TAC)
and other disease-modifying antirheumatic drugs (DMARDs). One hundred fifteen …

Reversible Cerebral Vasospasms Secondary to Spinal Subdural Hematoma: A Case Report

S Toyama, S Yazawa, A Sugimoto, T Murahara… - Clinical Neurology and …, 2020 - Elsevier
Discussion We described a case of RCVS in multiple intracranial vessels that was associated
with cerebral infarction in the right MCA territory preceded by SSDH. The features in the …

Autofeedback from ultrasound images provides rapid improvement in palpation skills for identifying joint swelling in rheumatoid arthritis.

…, Y YAMADA, T NEMOTO, M KAGEYAMA, S TOYAMA… - jrheum.org
Objective. Joint swelling, an important factor in the classification criteria and disease activity
assessment in rheumatoid arthritis (RA), renders joint palpation a necessary skill for …

[PDF][PDF] Research article Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice

S Toyama, N Tamura, K Haruta, T Karakida… - 2010 - arthritis-research.biomedcentral.com
Introduction: Targeting joint destruction induced by osteoclasts (OCs) is critical for management
of patients with rheumatoid arthritis (RA). Since phosphoinositide 3-kinase (PI3-K) plays …

Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317

H Toyama, S Sato, H Shirakawa, M Komai… - Bioorganic & Medicinal …, 2016 - Elsevier
We report the design, synthesis, and physicochemical/biological evaluation of novel silanol
derivative 6 (sila-T) as a silanol analog of multi-target nuclear receptor modulator T0901317 (…

The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD

H Umehara, K Okazaki, S Kawa… - Modern …, 2021 - academic.oup.com
IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century in
Japan, and includes a wide variety of diseases, such as formerly named Mikulicz's disease (…

Utility of nailfold capillary assessment for predicting psoriatic arthritis based on a prospective observational cohort study

T Fukasawa, S Toyama, A Enomoto… - …, 2023 - academic.oup.com
Objectives PsA is one of the most serious comorbidities associated with psoriasis. While the
early intervention in PsA is demanded, risk factors of PsA development are not well-known. …