A new experimental drug pirfenidone (5-methyl-1-phenyl-2-1H-pyridine-2-one) has been
reported to have beneficial effects for the treatment of certain fibrotic diseases. Here, we …

Objective To determine the change in metabolic activity of chondrocytes in osteoarthritic (OA)
cartilage, considering regional difference and degree of cartilage degeneration. Methods …

Background The epidermal growth factor (EGF) and EGF receptor (EGFR) families play
important roles in the hyperplastic growth of several tissues as well as tumor growth. Since …

In articular chondrocytes, the inflammatory cytokine tumor necrosis factor-α (TNF-α) induces
the expression of bone morphogenetic protein-2 (BMP-2), a growth factor known to be …

Tumor necrosis factor-α (TNF-α) is initially synthesized as a membrane-bound protein and
converted into a soluble form by proteolytic cleavage. Although a disintegrin and …

Background Although osteoarthritis (OA) of the knee joints is the most common and debilitating
joint disease in developed countries, the factors that determine the severity of symptoms …

We developed an adaptor ligation PCR-based microplate hybridization assay (MHA) to
analyze the repertoires of mouse T-cell receptor (TCR) α- and β-chain variable regions (TCRAV …

Transient receptor potential vanilloid 4 (TRPV4) receptor modulates pain, and this has been
noted in several animal models. However, the involvement of TRPV4 in osteoarthritic (OA) …

Numerous anti-mucin 1 (anti-MUC1) antibodies that recognize O-glycan core structures
have already been developed. However, most of them show low specificities toward O-glycan …

OBJECTIVE.: This study aimed to investigate the roles of the epidermal growth factor receptor
(EGFR) family members and their ligands in oral lichen planus (OLP). STUDY DESIGN.: …