A homology-based cDNA cloning approach was used to identify a widely expressed protein-tyrosine
kinase designated as "focal adhesion kinase" (FadK). The entire mouse FadK …

Identification of the genes underlying complex phenotypes and the definition of the
evolutionary forces that have shaped eukaryotic genomes are among the current challenges in …

Influenza A virus segment 2 is known to encode two polypeptides in overlapping open reading
frames: PB1, the polymerase, and PB1-F2, a proapoptotic virulence factor. We show that …

A new family of related ATPases has emerged, characterized by a highly conserved AAA
motif. This motif forms a 230-amino-acid domain that contains Walker homology sequences …

Retinoids exert their biologic effects through two families of nuclear receptors, retinoic acid
receptors (RARs) and retinoid X receptors (RXRs), which belong to the superfamily of …

Background: The epidermal growth factor receptor (EGFR) plays an important role in the
growth and survival of many human tumors of epithelial origin. EGFR variant III (EGFRvIII) is a …

We have cloned a gene (HSE1) from a human placental cDNA library that encodes a novel
protein exhibiting heparanase activity. The cDNA was identified through peptide sequences …

Retinoids exert their effect through ligand-dependent transcription factors, retinoic acid
receptors (RARα, β, and γ) and retinoid X receptor (RXRα, β, and γ), which belong to the …

Use of diagnostic imaging studies for evaluation of pregnant patients with medical conditions
not related to pregnancy poses a persistent and recurring dilemma. Although a theoretical …

… Patel under the direction of Karen M. O’Brien. The authors express appreciation to Jessica …
Correspondence concerning this article should be addressed to Sheetal G. Patel, Counseling …