Objective The 1980 American College of Rheumatology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

The aim was to update the 2009 European League against Rheumatism (EULAR)
recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic …

Objective. The 1980 American College of Rheuma-tology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

To examine whether the lack of sufficient neoangiogenesis in systemic sclerosis (SSc) is
caused by a decrease in angiogenic factors and/or an increase in angiostatic factors, the potent …

Objectives To identify overall disease course, progression patterns and risk factors
predictive for progressive interstitial lung disease (ILD) in patients with systemic sclerosis-associated …

Vasoconstriction accompanied by changes in skin color is a normal physiologic response to
cold. The distinction between this normal physiology and Raynaud's phenomenon (RP) has …

Objectives The EULAR (European League Against Rheumatism) Scleroderma Trials and
Research Group (EUSTAR) has identified preliminary criteria for very early diagnosis of …

Objective. To evaluate in SSc, the frequency of digital lesions and the morphology,
characteristics, natural course and time to healing of 1614 digital ulcers (DUs). Methods. One …

Objective Systemic sclerosis (SSc) features multiorgan fibrosis orchestrated predominantly
by activated myofibroblasts. Endothelial-to-mesenchymal transition (EndoMT) is a …

Multipotent mesenchymal stromal cells isolated from bone marrow and other sites are currently
being studied to determine their potential role in the pathogenesis and/or management of …