Cigarette smoking remains highly prevalent in most countries. It can affect drug therapy by
both pharmacokinetic and pharmacodynamic mechanisms. Enzymes induced by tobacco …

… Nicotine is also being investigated as a therapeutic agent for various conditions, including
ulcerative colitis, Parkinson’s disease, and Alzheimer’s dementia. Knowledge of the …

OBJECTIVES This study was designed to compare the effects of inhaled carbon monoxide (CO),
administered to achieve concentrations similar to those found in cigarette smoking, with …

We present two cases of rare human poisoning in one family following ingestion of cooked
leaves from the tobacco tree plant, Nicotiana glauca. The toxic principle of N. glauca, …

Aims Nicotine nasal spray and transdermal nicotine are effective aids to smoking cessation,
and are being evaluated for treatment of other medical diseases. Wide variation in levels of …

Enzyme replacement therapy (ERT) with imiglucerase reduces hepatosplenomegaly and
improves hematologic parameters in Gaucher disease type 1 within 6-24 months. Miglustat …

… Zimran A, Elstein D, Kannai R, Zevin S, Hadas-Halpern I, Levy-Lahad E, Cohen Y,
Horowitz M, Abrahamov A … Hollak CE, Aerts JM, Goudsmit R, Phoa SS, Ek M, van Weely S …

… Presumably, the cigarette smoking behavior persists as a highly conditioned behavior,
whereas the body’s need for and intake of nicotine is more physiologically regulated. …

… ulcerative colitis, Parkinson’s disease, and Alzheimer’s disease. l Because nicotine causes
sympathetic stimulation,2,3 there are some concerns about its safety, particularly when used …

Background Nicotine clearance and half‐life are known to be significantly reduced in
smokers compared to nonsmokers. Cotinine is the major primary metabolite of nicotine, and it …