Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency
in Caucasians. It has previously been suggested to be associated with a variety of …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

… Our data indicate that such a serologic screening is feasible and would be of considerable
help in the clinical management of patients in whom RA is predicted to develop. …

… an understanding of the etiology is dependent on the definition of … is the major known
environmental risk factor for RA, as is evident from epidemiologic studies (1-5), although little is …

… (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by …
Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong …

… (RA) is a common autoimmune disease that is characterized by … To date, it is unclear whether
it will be possible to fill this … The presence of ACPAs and/or RF is therefore not sufficient for …

Genome-wide association studies have recently identified at least 15 susceptibility loci for
systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from …

Using the Immunochip custom SNP array, which was designed for dense genotyping of 186
loci identified through genome-wide association studies (GWAS), we analyzed 11,475 …

… Systemic lupus erythematosus (SLE) is a complex systemic … of IFN-inducible genes is
commonly observed in SLE and may … 10 TYK2 binds to the type I IFN receptor complex and IRF5 is …

… with tumor necrosis factor (TNF) antagonists may increase the risk of tuberculosis (TB), and
because knowledge of the risk of TB in rheumatoid arthritis (RA) not treated with biologics is …