[HTML][HTML] Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 …
FE El Mansouri, SS Nebbaki, M Kapoor, H Afif… - Arthritis research & …, 2014 - Springer
… COX-1 is expressed in most tissues and is responsible for physiological production of PGs.
COX-2, in contrast, is almost undetectable under physiologic conditions, but it is strongly …
COX-2, in contrast, is almost undetectable under physiologic conditions, but it is strongly …
[HTML][HTML] Egr-1 contributes to IL-1-mediated down-regulation of peroxisome proliferator-activated receptor γ expression in human osteoarthritic chondrocytes
SS Nebbaki, FE El Mansouri, H Afif, M Kapoor… - Arthritis research & …, 2012 - Springer
… Osteoarthritis (OA) is the most common joint disease and is a leading cause of disability in
developed countries and throughout the world. Clinical manifestations of OA may include pain…
developed countries and throughout the world. Clinical manifestations of OA may include pain…
Expression of peroxisome proliferator-activated receptors α, β, γ, and H-and L-prostaglandin D synthase during osteoarthritis in the spontaneous hartley guinea pig …
SS Nebbaki, FE El Mansouri, H Afif, M Kapoor… - The Journal of …, 2013 - jrheum.org
… Osteoarthritis (OA) is the most common form of joint disorder worldwide and is frequently
associated with pain and functional impairment. OA is characterized by articular cartilage …
associated with pain and functional impairment. OA is characterized by articular cartilage …
Exacerbation of Aging‐Associated and Instability‐Induced Murine Osteoarthritis With Deletion of D Prostanoid Receptor 1, a Prostaglandin D2 Receptor
Y Ouhaddi, SS Nebbaki, L Habouri, H Afif… - Arthritis & …, 2017 - Wiley Online Library
… is primarily associated with antiinflammatory effects (16–27). In contrast, activation of DP2 is
… We have previously shown that DP1 is expressed in human cartilage and that the selective …
… We have previously shown that DP1 is expressed in human cartilage and that the selective …
THU0464 LSD1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1-induced microsomal prostaglandin e synthase-1 expression
FE El Mansouri, S Nebbaki, M Kapoor, H Afif… - Annals of the …, 2014 - ard.bmj.com
Background Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the terminal step
in the biosynthesis of PGE 2 , a critical mediator in the pathophysiology of osteoarthritis (OA)…
in the biosynthesis of PGE 2 , a critical mediator in the pathophysiology of osteoarthritis (OA)…
[HTML][HTML] Expression of PPAR a, b, g, and H-and L-PGDS during osteoarthritis in the spontaneous Hartley guinea pig and the experimental dog models
SS Nebbaki, FEL Mansouri, H Afif… - Osteoarthritis and …, 2013 - oarsijournal.com
Purpose: To investigate the expression of peroxisome proliferator-activated receptor (PPAR)
a, b, g, and hematopoietic and lipocaline-type prostaglandin D synthase (H-and L-PGDS) …
a, b, g, and hematopoietic and lipocaline-type prostaglandin D synthase (H-and L-PGDS) …
Egr-1 mediates the suppressive effect of IL-1 on PPARg expression in human OA chondrocytes
SS Nebbaki, FE El Mansouri, M Benderdour… - Arthritis Research & …, 2012 - Springer
Background Peroxisome proliferator-activated receptor gamma (PPARg) is a ligand activated
transcription factor and member the nuclear hormone receptor superfamily. Several lines …
transcription factor and member the nuclear hormone receptor superfamily. Several lines …
LSD1-mediated demethylation of histone h3 lysine 9 contributes to interleukin 1-induced microsomal prostaglandin e synthase-1 expression in human osteoarthritic …
FE El Mansouri, SS Nebbaki, H Afif… - Osteoarthritis and …, 2014 - oarsijournal.com
Purpose: Microsomal prostaglandin E synthase-1 catalyzes the terminal step in the
biosynthesis of PGE2, which plays a critical role in the pathophysiology of osteoarthritis. To …
biosynthesis of PGE2, which plays a critical role in the pathophysiology of osteoarthritis. To …
Expression of PPARα, β, and γ in the Hartley guinea pig model of primary osteoarthritis
F El Mansouri, S Nebbaki, N Zayed… - Osteoarthritis and …, 2012 - oarsijournal.com
Purpose: To investigate the expression of PPARα, β, and γ in cartilage over the course of
osteoarthritis (OA) in the spontaneous Hartley guinea pig model. Methods: Hartley guinea pigs …
osteoarthritis (OA) in the spontaneous Hartley guinea pig model. Methods: Hartley guinea pigs …
Egr-1 mediates the suppressive effect of IL-1 on PPARγ expression in human OA chondrocytes
SS Nebbaki, F Ezzahra El Mansouri, N Zayed… - Journal of Translational …, 2012 - Springer
… This article is published under license to BioMed Central Ltd. This is an Open Access
article distributed under the terms of the Creative Commons Attribution License (http://…
article distributed under the terms of the Creative Commons Attribution License (http://…