Background Telephone consultation is the process where calls are received, assessed and
managed by giving advice or by referral to a more appropriate service. In recent years there …

Background Patient and public involvement (PPI) is a prerequisite for many funding bodies
and NHS research ethics approval. PPI in research is defined as research carried out with or …

Background In recent years there has been a growth in the use of the telephone consultation
for healthcare problems. This has developed, in part, as a response to increased demand …

Immune checkpoint inhibitor (ICI) treatments benefit some patients with metastatic cancers,
but predictive biomarkers are needed. Findings in selected cancer types suggest that tumor …

The mechanisms by which immune checkpoint blockade modulates tumor evolution during
therapy are unclear. We assessed genomic changes in tumors from 68 patients with …

CD8 + T cell–dependent killing of cancer cells requires efficient presentation of tumor
antigens by human leukocyte antigen class I (HLA-I) molecules. However, the extent to which …

Background ExteNET showed that 1 year of neratinib, an irreversible pan-HER tyrosine
kinase inhibitor, significantly improves 2-year invasive disease-free survival after trastuzumab-…

Much of the current work in distributed, object-oriented systems is based on the assumption
that objects form a single ontological class. This class consists of all entities that can be fully …

Central mechanisms related to referred muscle pain and temporal summation of muscular
nociceptive activity are facilitated in fibromyalgia syndrome (FMS) patients. The present study …

… The word in language is half someone else s. It becomes 'one's own only when the speaker
populates it. . . Prior to this moment of appropriation, the word does not exist in a neutral and …