Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor,
are generally favored for their ability to obtain quantitative data on intermolecular binding. …

Hirschsprung disease (HSCR, aganglionic megacolon) represents the main genetic cause
of functional intestinal obstruction with an incidence of 1/5000 live births. This developmental …

Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and type …

… Following an approach pioneered by Pearson (1903), this analysis helps to reveal the
target(s) of selection, and to quantify its intensity, without identifying the selective agent(s). By …

The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association
study of late-onset Alzheimer disease using a three-stage design consisting of a discovery …

Background Community-acquired pneumonia is a leading infectious cause of hospitalization
and death among US adults. Incidence estimates of pneumonia confirmed radiographically …

Background Incidence estimates of hospitalizations for community-acquired pneumonia
among children in the United States that are based on prospective data collection are limited. …

Importance Cerebral amyloid-β aggregation is an early pathological event in Alzheimer
disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid …

… S is a column vector of selection differentials or shifts in character means due to selection
within a generation. In other words, G describes inheritance, P describes character variation, S …

While a potential causal factor in Alzheimer’s disease (AD), brain insulin resistance has not
been demonstrated directly in that disorder. We provide such a demonstration here by …