Objective: To assess internists' familiarity with, confidence in, and attitudes about practice
guidelines issued by various organizations. Design: Cross-sectional, self-administered survey. …

Decision makers in health care are increasingly interested in using high-quality scientific
evidence to support clinical and health policy choices; however, the quality of available …

This article defines and describes best practices for the academic and business community
to generate evidence of clinical utility for cancer molecular diagnostic assays. Beyond …

Policy makers have clearly indicated – through heavy investment in the Patient Centered
Outcomes Research Institute – that reporting outcomes that are meaningful to patients is crucial …

CLINICAL SCENARIO You are relieved to find that the last patient in your busy primary care
clinic is a previously well 48-year-old woman with acute dysuria. There has been no …

Aims: Stakeholder engagement is fundamental to comparative effectiveness research (CER),
but lacks consistent terminology. This paper aims to define stakeholder engagement and …

CLINICAL SCENARIO At the conclusion of our first article on practice guidelines 1 in this
series, we left you examining the full text of a practice guideline 2 that could help you marshal a …

… Her recent accomplishments include serving as a senior editor … Sean Tunis is the founder
and director of the Center for Medical … Tunis advises health care organizations on comparative …

Background. Percutaneous transluminal angioplasty has been adopted widely as a treatment
for patients with peripheral vascular disease of the lower extremities. However, the effect of …

Background: Internationally, many health care interventions were diffused prior to the standard
use of assessments of safety, effectiveness and cost-effectiveness. Disinvestment from …