ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action
…, RD Brokx, TA Denny, TA Hembrough, SM Plum… - Molecular cancer …, 2011 - AACR
ENMD-2076 is a novel orally active, small molecule kinase inhibitor with a mechanism of action
involving several pathways key to tumor growth and survival: angiogenesis, proliferation, …
involving several pathways key to tumor growth and survival: angiogenesis, proliferation, …
[HTML][HTML] Endostatin binds tropomyosin: a potential modulator of the antitumor activity of endostatin
…, WY Shivers, DL Narum, SM Plum… - Journal of Biological …, 2001 - ASBMB
The mechanism of action of Endostatin, an endogenous inhibitor of angiogenesis and tumor
growth, remains unknown. We utilized phage-display technology to identify polypeptides …
growth, remains unknown. We utilized phage-display technology to identify polypeptides …
Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumor growth
…, CB Underhill, Z Han, F Gao, G Swartz, SM Plum… - Cancer research, 2001 - AACR
In this study, a hyaluronan-binding complex, which we termed Metastatin,was isolated from
bovine cartilage by affinity chromatography and found to have both antitumorigenic and …
bovine cartilage by affinity chromatography and found to have both antitumorigenic and …
Administration of a liposomal FGF-2 peptide vaccine leads to abrogation of FGF-2-mediated angiogenesis and tumor development
SM Plum, JW Holaday, A Ruiz, JW Madsen, WE Fogler… - Vaccine, 2000 - Elsevier
Basic fibroblast growth factor (FGF-2) is an important stimulator of angiogenesis that has been
implicated in neoplastic progression. Attempts to neutralize or modulate FGF-2 have met …
implicated in neoplastic progression. Attempts to neutralize or modulate FGF-2 have met …
Recombinant prostate specific antigen inhibits angiogenesis in vitro and in vivo
…, DK Grella, J Holland‐Linn, H Vu, SM Plum… - The …, 2003 - Wiley Online Library
BACKGROUND Prostate specific antigen (PSA) is a kallikrein family member with serine
protease activity commonly used as a diagnostic marker for prostate cancer. We recently …
protease activity commonly used as a diagnostic marker for prostate cancer. We recently …
Identification and characterization of a very low density lipoprotein receptor-binding peptide from tissue factor pathway inhibitor that has antitumor and antiangiogenic …
…, GM Swartz, HJ Hammers, L Zhang, SM Plum… - Blood, 2004 - ashpublications.org
Tissue factor pathway inhibitor (TFPI) is the major physiologic inhibitor of the extrinsic
coagulation pathway. We have previously shown that TFPI is also a potent inhibitor of endothelial …
coagulation pathway. We have previously shown that TFPI is also a potent inhibitor of endothelial …
[HTML][HTML] Disease modifying and antiangiogenic activity of 2-methoxyestradiol in a murine model of rheumatoid arthritis
SM Plum, EJ Park, SJ Strawn, EG Moore… - BMC musculoskeletal …, 2009 - Springer
… Stacy M Plum … Brahn E, Banquerigo ML, Park EJ, Fogler WE, Plum SM: An Angiogenesis
Inhibitor, 2-Methoxyestradiol, Involutes Rat Collagen-Induced Arthritis and … Stacy M Plum …
Inhibitor, 2-Methoxyestradiol, Involutes Rat Collagen-Induced Arthritis and … Stacy M Plum …
Synergistic Activity of Recombinant Human Endostatin in Combination with Adriamycin: Analysis of in Vitro Activity on Endothelial Cells and in Vivo Tumor …
SM Plum, AD Hanson, KM Volker, HA Vu, BKL Sim… - Clinical cancer …, 2003 - AACR
Purpose: Current combination treatment strategies in malignancy are designed to evaluate
the use of cytotoxic drugs and antiangiogenic agents. Endostatin, a fragment of collagen XVIII…
the use of cytotoxic drugs and antiangiogenic agents. Endostatin, a fragment of collagen XVIII…
An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses gene expression of synovial vascular endothelial growth factor …
…, JK Lee, EJ Park, WE Fogler, SM Plum - The Journal of …, 2008 - jrheum.org
Objective Rheumatoid arthritis (RA) pannus may be dependent on angiogenesis and
several critical growth factors including vascular endothelial growth factor (VEGF) and basic …
several critical growth factors including vascular endothelial growth factor (VEGF) and basic …
Generation of a Specific Immunological Response to FGF‐2 Does Not Affect Wound Healing or Reproduction
SM Plum, HA Vu, B Mercer, WE Fogler… - Immunopharmacology …, 2004 - Taylor & Francis
Angiogenesis, the process of new capillary formation from pre‐existing vessels, has been
established as an important mechanism involved in pathologic processes, such as cancer, as …
established as an important mechanism involved in pathologic processes, such as cancer, as …