MAJOR histocompatibility complex (MHC) class I and class II molecules bind immunogenic
peptides and present them to lymphocytes bearing the αβ T-cell antigen receptor (TCR) 1–4 . …

Natural killer T (NKT) cells recognize glycosphingolipids presented by CD1d molecules and
have been linked to defense against microbial infections. Previously defined foreign …

Two different forms of death are commonly observed when Mycobacterium tuberculosis (Mtb)-infected
macrophages die: (i) necrosis, a death modality defined by cell lysis and (ii) …

NKT cells are associated with immunological control of autoimmune disease and cancer
and can recognize cell surface mCD1d without addition of exogenous antigens. Cellular …

We report that dissemination of Mycobacterium tuberculosis in the mouse is under host
control and precedes the initiation of T-cell immunity. Nine to eleven days after aerosol …

Virulent Mycobacterium tuberculosis inhibits apoptosis and triggers necrosis of host
macrophages to evade innate immunity and delay the initiation of adaptive immunity. By contrast, …

Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and results
are starting to come in. Some of these results are not so encouraging, as exemplified by the …

… We have found that 40–60% of the CD4 + T cells in the lungs of infected mice are primed
to produce IFN-γ (Chackerian, A., and SM Behar, manuscript in preparation), and it remains to …

… Behar; Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis
… Nandi and SM Behar conceived of and designed the experiments, analyzed the data, and …

Virulent Mycobacterium tuberculosis (Mtb) induces a maladaptive cytolytic death modality,
necrosis, which is advantageous for the pathogen. We report that necrosis of macrophages …