Objective To develop criteria for the classification of macrophage activation syndrome (MAS)
in patients with systemic juvenile idiopathic arthritis (JIA). Methods A multistep process, …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that causes substantial
morbidity. As is typical for many other multifactorial disorders, much of the heritability of …

Juvenile Idiopathic Arthritis (JIA) is a group of chronic heterogenous disorders that manifests
as joint inflammation in patients aged <16 years. Globally, approximately 3 million children …

Recent therapeutic advances in juvenile idiopathic arthritis (JIA) have made remission an
achievable goal for most patients. Reaching this target leads to improved outcomes. The …

In this study, we report the experience of the only reference clinical next-generation sequencing
lab in Saudi Arabia with the first 1000 families who span a wide-range of suspected …

Objective To evaluate genetic, demographic and clinical features in patients with cryopyrin-associated
periodic syndrome (CAPS) from the Eurofever Registry, with a focus on genotype-…

Objective To determine the clinical and immunologic features of systemic sclerosis (SSc) in
a large group of children and describe the clinical evolution of the disease and compare it …

Background To our knowledge, the characteristics and burden of childhood arthritis have
never been studied on a worldwide basis. We aimed to investigate, with a cross-sectional study…

Background and aim Familial Mediterranean fever (FMF) is an autoinflammatory disease
caused by mutations of the MEFV gene. We analyse the impact of ethnic, environmental and …

Objective To assess the efficacy of intravenous immunoglobulin (IVIG) for the treatment of
juvenile dermatomyositis (JDM) in patients who were unresponsive to corticosteroids (steroid …