… The present article is an update and extension of an earlier review published by Kwan
Tat et al. [Kwan Tat S, Padrines M, Théoleyre S, Heymann D, Fortun Y. IL-6, RANKL, TNF-α/IL-1: …

Over the past few decades, significant progress has been made with respect to new
concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the …

Bone remodelling is tightly regulated by a molecular triad composed of OPG/RANK/RANKL.
The receptor activator of NF-κB ligand (RANKL)(localized on osteoblasts) enhances …

Early in the pathological process of osteoarthritis (OA), subchondral bone remodelling, which
is related to altered osteoblast metabolism, takes place. In the present study, we explored …

INTRODUCTION: In osteoarthritis (OA) the progression of cartilage degeneration has been
associated with remodeling of the subchondral bone. Human OA subchondral bone …

Objective We previously reported that human OA subchondral bone osteoblasts could be
discriminated into two subpopulations identified by their levels of endogenous production (low […

OBJECTIVE: Osteoarthritis is a chronic disease characterized by irreversible damage to joint
structures, including loss of articular cartilage, inflammation of the synovial membrane, and …

Osteoprotegerin (OPG) is a decoy receptor for receptor activator of nuclear factor κB ligand (RANKL),
a key inducer of osteoclastogenesis via its receptor RANK. We previously showed …

Introduction Subchondral bone alterations represent an essential component of osteoarthritis
(OA). Modifying the abnormal subchondral bone metabolism may be indicated to treat OA. …

Objective. During osteoarthritis (OA), the altered metabolism of cartilage involves proinflammatory
factors and matrix metalloprotease (MMP) activity. Studies showed that chondroitin …