The genetic basis of bipolar disorder has long been thought to be complex, with the potential
involvement of multiple genes, but methods to analyze populations with respect to this …

We have determined the structure of the human glucocorticoid receptor (hGR) gene after
the isolation and characterization of cosmid clones mapping to discrete regions of the cDNA. …

… For these 18 studies, an average of 404.2 (SD 122.9) markers were tested per scan, or 3.37
(SD 1.02) per 30-cM bin. Of the 18 scans, 13 had markers in all bins, 4 had no markers in 1–…

… Encio IJ, Detera-Wadleigh S. The genomic structure of the human glucocorticoid receptor. J
… Karl M, Lamberts SW, Detera-Wadleigh S, et al. Familial glucocorticoid resistance caused by …

Bipolar disorder is a severe mental illness characterized by mood swings of elation and
depression. Family, twin, and adoption studies suggest a complex genetic etiology that may …

… , two negative glucocorticoid receptor elements, and an AP1 site have been identified,
although it is not yet clear whether these elements are active (63; Encio and Detera-Wadleigh. …

Association of the G72/G30 locus with schizophrenia and bipolar disorder has now been
reported in several studies. The G72/G30 locus may be one of several that account for the …

… into yeast strain AH109 and plated on an SD-Trp plate. An overnight culture (concentrated
culture) of positive pGBKT7-CADPS2 (134–331 aa) bait strain in SD/-Trp medium was used to …

… DETERA-WADLEIGH, IGNACIO J. ENCIO, CONSTANTINE … Encio IJ, Detera-Wadleigh
SD. 1991 The genomic structure of the human glucocorticoid …

Two recent reports have highlighted ANK3 as a susceptibility gene for bipolar disorder (BD).
We first reported association between BD and the ANK3 marker rs9804190 in a genome-…