SMAD3 is upregulated in human osteoarthritic cartilage independent of the promoter DNA methylation
E Aref-Eshghi, M Liu, SB Razavi-Lopez… - The Journal of …, 2016 - jrheum.org
Objective. To compare SMAD3 gene expression between human osteoarthritic and healthy
cartilage and to examine whether expression is regulated by the promoter DNA methylation …
cartilage and to examine whether expression is regulated by the promoter DNA methylation …
Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus
S Hackinger, K Trajanoska… - Human molecular …, 2017 - academic.oup.com
Osteoarthritis (OA) is a common complex disease with high public health burden and no
curative therapy. High bone mineral density (BMD) is associated with an increased risk of …
curative therapy. High bone mineral density (BMD) is associated with an increased risk of …
[HTML][HTML] Investigating the mechanism by which SMAD3 induces PAX6 transcription to promote the development of non-small cell lung cancer
Z Qian, Q Zhang, Y Hu, T Zhang, J Li, Z Liu, H Zheng… - Respiratory …, 2018 - Springer
Background This study investigated the function of SMAD3 (SMAD family member 3) in
regulating PAX6 (paired box 6) in non-small cell lung cancer. Methods First, qRT-PCR was …
regulating PAX6 (paired box 6) in non-small cell lung cancer. Methods First, qRT-PCR was …
The polymorphism of SMAD3 rs1065080 is associated with increased risk for knee osteoarthritis
C Lu, J Shu, Y Han, XY Ren, K Xu, H Fan… - Molecular biology …, 2019 - Springer
The mechanism of knee osteoarthritis (OA) is still not clearly elucidated. SMAD3 gene
polymorphisms are considered to play a vital role in OA pathogenesis. We thus investigated the …
polymorphisms are considered to play a vital role in OA pathogenesis. We thus investigated the …
[HTML][HTML] Macrophage migration inhibitory factor may play a protective role in osteoarthritis
M Liu, Z Xie, G Sun, L Chen, D Qi, H Zhang… - Arthritis Research & …, 2021 - Springer
Background Osteoarthritis (OA) is the most prevalent form of arthritis and the major cause of
disability and overall diminution of quality of life in the elderly population. Currently there is …
disability and overall diminution of quality of life in the elderly population. Currently there is …
Epigenetic regulation of 15-lipoxygenase-1 expression in human chondrocytes by promoter methylation
SG Alsabri, GG Guedi, M Najar, M Merimi, F Lavoie… - Inflammation …, 2023 - Springer
Objective and design 15-Lipoxygenase-1 (15-LOX-1) catalyzes the biosynthesis of many
anti-inflammatory and immunomodulatory lipid mediators and was reported to have protective …
anti-inflammatory and immunomodulatory lipid mediators and was reported to have protective …
[HTML][HTML] At the crux of joint crosstalk: TGFβ signaling in the synovial joint
KN Bailey, T Alliston - Current rheumatology reports, 2022 - Springer
Purpose of Review The effect of the transforming growth factor beta (TGFβ) signaling pathway
on joint homeostasis is tissue-specific, non-linear, and context-dependent, representing a …
on joint homeostasis is tissue-specific, non-linear, and context-dependent, representing a …
Clinical relevance of biochemical and metabolic changes in osteoarthritis
G Zhai - Advances in Clinical Chemistry, 2021 - Elsevier
Osteoarthritis (OA) is a multifactorial disease with huge phenotypic heterogeneity. The disease
affects all tissues in the joint, and the loss of articular cartilage is its hallmark. The main …
affects all tissues in the joint, and the loss of articular cartilage is its hallmark. The main …
[HTML][HTML] Systematic analysis of transcriptomic profile of chondrocytes in osteoarthritic knee using next-generation sequencing and bioinformatics
YJ Chen, WA Chang, LY Wu, YL Hsu, CH Chen… - Journal of Clinical …, 2018 - mdpi.com
The phenotypic change of chondrocytes and the interplay between cartilage and subchondral
bone in osteoarthritis (OA) has received much attention. Structural changes with nerve …
bone in osteoarthritis (OA) has received much attention. Structural changes with nerve …
[BOOK][B] Mechanobiologic Mechanisms of Osteocyte Regulation of Bone-Cartilage Crosstalk
K Bailey - 2020 - search.proquest.com
Osteoarthritis (OA) is a degenerative joint disease characterized by disruption of multiple joint
tissues, including articular cartilage and subchondral bone, resulting in chronic joint pain. …
tissues, including articular cartilage and subchondral bone, resulting in chronic joint pain. …