BACKGROUND: Joint space width (JSW) evaluated in millimeters on plain X-rays is the
currently optimal recognized technique to evaluate osteoarthritis (OA) structural progression. …

Objective To determine whether baseline lower extremity muscle weakness is a risk factor
for incident radiographic osteoarthritis (OA) of the knee. Methods This prospective study …

A pool of 320 articles on patient education were screened to select controlled experiments in
chronic disease where the dependent variables included (a) compliance with a therapeutic …

Objective Quadriceps weakness is a risk factor for incident knee osteoarthritis (OA). We describe
a randomized controlled trial of effects of lower‐extremity strength training on incidence …

Background: Improving a patient's ability to self-monitor and manage changes in chronic
obstructive pulmonary disease (COPD) symptoms may improve outcomes. Objective: To …

Objective To confirm preclinical data suggesting that doxycycline can slow the progression
of osteoarthritis (OA). The primary outcome measure was joint space narrowing (JSN) in the …

The Diabetes Education Study (DIABEDS) was a randomized, controlled trial of the effects of
patient and physician education. This article describes a systematic education program for …

MUCH interest currently exists in the possibility of pharmacologically modifying the disease
process in osteoarthritis (OA). A number of pharmacologic agents have been shown to …

Statistical regression to the mean predicts that patients selected for abnormalcy will, on the
average, tend to improve. We argue that most improvements attributed to the placebo effect …

Objective To evaluate progression of joint space narrowing in radiographs of osteoarthritic (OA)
knees imaged in both the standing anteroposterior (AP) and the Lyon schuss positions, …