Emerging evidence demonstrates that the DNA repair kinase DNA-PKcs exerts divergent
roles in transcriptional regulation of unsolved consequence. Here, in vitro and in vivo …

Purpose To test the hypothesis that a genomic classifier (GC) would predict biochemical
failure (BF) and distant metastasis (DM) in men receiving radiation therapy (RT) after radical …

Increasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22)
deubitiquitylase to cancer development and progression in a select group of tumor types, but its …

Mutations in the BRCA1 tumor suppressor gene are commonly found in hereditary breast
cancer. Similarly, downregulation of BRCA1 protein expression is observed in the majority of …

Here, we developed a model system to evaluate the metabolic effects of oncogene(s) on the
host microenvironment. A matched set of “normal” and oncogenically transformed epithelial …

A subgroup of breast cancers has several metabolic compartments. The mechanisms by
which metabolic compartmentalization develop in tumors are poorly characterized. TP53 …

Introduction: Monocarboxylate transporter 1 (MCT1) is an importer of monocarboxylates
such as lactate and pyruvate and a marker of mitochondrial metabolism. MCT1 is highly …

Breast cancer is composed of metabolically coupled cellular compartments with upregulation
of TP53 Induced Glycolysis and Apoptosis Regulator (TIGAR) in carcinoma cells and loss …

Cancer mucosa antigens are emerging as a new category of self-antigens expressed normally
in immunologically privileged mucosal compartments and universally by their derivative …

Rosai-Dorfman disease (RDD), also known as sinus histocytosis with massive lymphadenopathy,
is a clinically benign, frequently chronic, painless lymphadenopathy. It can also …