Complement-mediated tissue injury in humans occurs upon deposition of immune complexes,
such as in autoimmune diseases and acute respiratory distress syndrome. Acute lung …

Damage to human skin due to ultraviolet light from the sun (photoaging) and damage occurring
as a consequence of the passage of time (chronologic or natural aging) are considered …

Sepsis in humans is a difficult condition to treat and is often associated with a high mortality
rate. In this study, we induced sepsis in rats using cecal ligation and puncture (CLP). In rats …

The complement activation product, C5a, may play a key role in the acute inflammatory
response. Polyclonal antibody to rat C5a was used to define the requirements for C5a in …

The objective of this study was to assess matrix metalloproteinase (MMP) and MMP inhibitor
expression in the airspace of patients with acute lung injury (ALI) or acute respiratory …

The role of endogenous NO in the regulation of acute lung injury is not well defined. We
investigated the effects of inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) …

Matrix metalloproteinases (MMPs) are upregulated locally in sites of inflammation, including
the lung. Several MMP activities are upregulated in acute lung injury models but the exact …

To assess the potential of individual bile acids (IBA) and their profiles as mechanistic
biomarkers of liver injury for humans in real world situations, we interrogated samples collected …

Objective To identify circulating proteins that distinguish between active anti-neutrophil
cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and remission in a manner …

The role of the CC chemokines, macrophage inflammatory protein-1β (MIP-1β), monocyte
chemotactic peptide-1 (MCP-1), and RANTES, in acute lung inflammatory injury induced by …