Longterm safety and efficacy of tocilizumab in patients with rheumatoid arthritis: a cumulative analysis of up to 4.6 years of exposure

…, J Gómez-Reino, A Sebba, R Pilson… - The Journal of …, 2013 - jrheum.org
Objective. To assess the longterm safety and efficacy of tocilizumab (TCZ) in patients with
moderate to severe rheumatoid arthritis (RA). Methods. Patient data were from 5 randomized …

Coadministration of lorcaserin and phentermine for weight management: A 12‐week, randomized, pilot safety study

…, WT Garvey, FL Greenway, S Zhou, R Fain, R Pilson… - …, 2017 - Wiley Online Library
Objective To assess the short‐term tolerability of lorcaserin alone or with two dose regimens
of phentermine. Methods This was a 12‐week, randomized, double‐blind, pilot safety study …

Reduced immunogenicity and improved pharmacokinetics of humanized anti-Tac in cynomolgus monkeys.

…, P Bailon, JA Kondas, RS Pilson… - … (Baltimore, Md.: 1950 …, 1991 - journals.aai.org
The anti-Tac mAb has been shown to bind to the p55 chain of the IL-2R, block IL-2 binding
and inhibit T cell proliferation. A humanized form of anti-Tac (HAT) has been constructed that …

Humanized antibodies against the alpha-chain of the IL-2 receptor and against the beta-chain shared by the IL-2 and IL-15 receptors in a monkey uveitis model of …

…, MS Kriete, J Benichou, RS Pilson… - … (Baltimore, Md.: 1950 …, 1997 - journals.aai.org
We studied the efficacy and tolerance of humanized Ab interfering with the signal of the IL-2
and IL-15 receptors in a primate model of experimental autoimmune uveoretinitis. The …

Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab

…, R Benayed, O Spleiss, A Platt, R Pilson… - Pharmacogenetics …, 2011 - journals.lww.com
Objective Tocilizumab, a monoclonal antibody to interleukin-6 receptor, was recently approved
for the treatment of moderate-to-severe rheumatoid arthritis. Two patients during clinical …

Challenges of antiretroviral treatment in transient and drug-using populations: the SUN study

…, E Graham, P Siemon-Hryczyk, RS Pilson - AIDs Patient Care …, 2001 - liebertpub.com
This is an open-label, single-arm, phase 3b study (part of phase 3 development) to evaluate
the efficacy and safety of Fortovase-soft gelatin formulation (saquinavir-SGC), combined …

Efficacy and safety of twice-daily versus three-times daily saquinavir soft gelatin capsules as part of triple combination therapy for HIV-1 infection

…, C Cohen, G Pierone, J Lalezari, RS Pilson… - Antiviral …, 2002 - journals.sagepub.com
Objective The objective of this study was to determine whether a triple therapy regimen
incorporating twice-daily saquinavir is as effective as a three-times daily regimen. Methods This …

Long-term efficacy and safety of twice-daily saquinavir soft gelatin capsules (SGC), with or without nelfinavir, and three times daily saquinavir-SGC, in triple …

…, J Feinberg, J Goodrich, RS Pilson… - Antiviral …, 2003 - journals.sagepub.com
Objectives To evaluate the long-term efficacy and safety of saquinavir soft gelatin capsules (SQV-SGC)
(Fortovase®) in twice-daily, with or without nelfinavir (NFV), and three-times-daily …

ISOLATION AND PURIFICATION OF ANTIGEN-SPECIFIC INDUCER AND SUPPRESSOR FACTORS FROM POOLED LEUKOCYTE DIALYSATES OF UNSELECTED …

RS Holzman, W Borkowsky, R Pilson… - … of Transfer Factor, 1983 - Elsevier
Publisher Summary It has been shown that antigen-specific inducer and suppressor factors
may be isolated from dialysates of leukocyte extracts (DLE) by affinity adsorption and …

Dialyzable lymphoid extract (DLE) from mice resistant to STZ-induced diabetogenesis can interrupt the progress of diabetes in STZ-treated CD-1 mice

W Borkowsky, R Pilson, HS Lawrence - Biotherapy, 1996 - Springer
DLE was prepared from the minority of euglycemic CD-1 mice, previously injected with STZ,
and was administered to hyperglycemic CD-1 male mice 1, 2 and 3 weeks after completion …