Background Vitamin D deficiency is a major risk factor for bone loss and fracture. Although
hypovitaminosis D has been detected frequently in elderly and housebound people, the …

Denosumab is a fully human monoclonal antibody that inhibits bone resorption by neutralizing
RANKL, a key mediator of osteoclast formation, function, and survival. This phase 3, …

The role of modelling in economic evaluation is explored by discussing, with examples, the
uses of models. The expanded use of pragmatic clinical trials as an alternative to models is …

Background. Osteoporosis among older women is a major public health problem. We studied
the effects of three approaches to the prevention of osteoporosis in women with low bone …

The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF
≤ 1%) variants contribute to complex traits and disease in the general population is …

Background Increased dietary calcium intake has been proposed as a population-based
public health intervention to prevent osteoporotic fractures. We have examined whether …

The influence of urinary sodium excretion and dietary calcium intake was examined in a 2-y
longitudinal study of bone density in 124 women postmenopausal for < 10 y. Analysis of …

OBJECTIVES: To examine whether fear of falling is a probable cause of reduced recreational
physical activity levels in healthy older women. DESIGN: Cross‐sectional analysis of …

We aimed to identify genetic variants associated with cortical bone thickness (CBT) and
bone mineral density (BMD) by performing two separate genome-wide association study (GWAS…

Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral
density (BMD) is a major predisposing factor to fracture and is known to be highly heritable…