The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification.
We have used haplotype analysis of linkage disequilibrium to spotlight a small segment …

Objective. —To examine more closely the association between apolipoprotein E (APOE)
genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

In postmortem brain specimens from 163 clinically diagnosed cases of Huntington's disease
(HD) the striatum exhibited marked variation in the severity of neuropathological …

We conducted a meta-analysis of Parkinson's disease genome-wide association studies
using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six …

Alzheimer's disease is a leading cause of morbidity and mortality among the elderly. Several
families have been described in which Alzheimer's disease is caused by an autosomal …

Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a
unique tool for the study of human disease, as well as a promising source for cell …

BACKGROUND Genetic lipoprotein disorders have been associated with premature coronary
artery disease (CAD). METHODS AND RESULTS The prevalence of such disorders was …

Hypertension is a leading cause of morbidity and mortality. Efforts to identify hypertension
genes have focused on 3 approaches: mendelian disorders, candidate genes, and genome-…

We compared the number of CAG repeats, the age at death, and the severity of neuropathology
in 89 Huntington's disease brains. We found a linear correlation between the CAG …