The heterogeneity of common variable immunodeficiency (CVID) calls for a classification
addressing pathogenic mechanisms as well as clinical relevance. This European multicenter …

The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of
immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family …

Microbes or danger signals trigger inflammasome sensors, which induce polymerization of
the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase-…

TREX1 acts in concert with the SET complex in granzyme A–mediated apoptosis, and
mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain lupus. Here, we …

Background Common variable immunodeficiency (CVID) is an antibody deficiency with an
equal sex distribution and a high variability in clinical presentation. The main features include …

Objectives: To evaluate metabolic abnormalities, beta-cell function, lipid profile and
vascular risk factors in HIV patients on protease inhibitors (PI). Design: Prospective cross-sectional …

In this study we present new differential characteristics of NK cells expressing CD56 surface
antigen in low (CD56 dim ) or high (CD56 bright ) density. In contrast to CD56 bright NK …

The family of receptors for IgG (FcγR) plays an essential role in antibody-mediated effector
functions of the immune system. However, the specific contribution of each of the FcγR …

Background The flavivirus GB virus C (GBV-C, also designated hepatitis G virus) was identified
in a search for hepatitis viruses, but no disease is currently known to be associated with it…

IgG Fc receptors (FcγRs, especially FcγRIII) and complement (in particular, C5a anaphylatoxin)
are critical effectors of the acute inflammatory response to immune complexes (ICs). …