ContextDespite decades of accumulated observational evidence, the balance of risks and
benefits for hormone use in healthy postmenopausal women remains uncertain.ObjectiveTo …

ContextPostmenopausal women have a greater risk than men of developing Alzheimer
disease, but studies of the effects of estrogen therapy on Alzheimer disease have been …

Importance Menopausal hormone therapy continues in clinical use but questions remain
regarding its risks and benefits for chronic disease prevention. Objective To report a …

Background The efficacy of calcium with vitamin D supplementation for preventing hip and
other fractures in healthy postmenopausal women remains equivocal. Methods We recruited …

ContextIn the Women's Health Initiative trial of estrogen-plus-progestin therapy, women
assigned to active treatment had fewer fractures.ObjectiveTo test the hypothesis that the relative …

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Background. To determine the effects of etidronate (a bisphosphonate that inhibits
osteoclast-mediated bone resorption) in the treatment of postmenopausal osteoporosis, we …

ContextThe hypothesis that a low-fat dietary pattern can reduce breast cancer risk has existed
for decades but has never been tested in a controlled intervention trial.ObjectiveTo assess …

Background Higher intake of calcium and vitamin D has been associated with a reduced risk
of colorectal cancer in epidemiologic studies and polyp recurrence in polyp-prevention trials…

ContextPostmenopausal hormone replacement therapy (HRT) has been shown to elevate C-reactive
protein (CRP) levels. Several inflammatory biomarkers, including CRP, are …