Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome

RK Gherardi, L Belec, M Soubrier, D Malapert, M Zuber… - 1996 - ashpublications.org
The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS)
syndrome is a rare multisystem disorder of obscure pathogenesis associated with osteosclerotic …

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

…, N Van Rooijen, A Plonquet, RK Gherardi… - The Journal of …, 2007 - rupress.org
Macrophages (MPs) are important for skeletal muscle regeneration in vivo and may exert
beneficial effects on myogenic cell growth through mitogenic and antiapoptotic activities in vitro…

Muscle satellite cells and endothelial cells: close neighbors and privileged partners

…, S Tajbakhsh, B Chazaud, RK Gherardi - Molecular biology of …, 2007 - Am Soc Cell Biol
Genetically engineered mice (Myf5 nLacZ/+ , Myf5 GFP-P/+ ) allowing direct muscle satellite
cell (SC) visualization indicate that, in addition to being located beneath myofiber basal …

Satellite cells attract monocytes and use macrophages as a support to escape apoptosis and enhance muscle growth

…, F Poron, FJ Authier, PA Dreyfus, RK Gherardi - The Journal of cell …, 2003 - rupress.org
Once escaped from the quiescence niche, precursor cells interact with stromal components
that support their survival, proliferation, and differentiation. We examined interplays between …

Dual and beneficial roles of macrophages during skeletal muscle regeneration

…, H Yacoub-Youssef, L Arnold, R Gherardi… - Exercise and sport …, 2009 - journals.lww.com
Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits
inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon …

Lipid‐lowering drugs and mitochondrial function: effects of HMG‐CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio

…, A Astier, B Jacotot, R Gherardi - British journal of …, 1996 - Wiley Online Library
1Statins inhibit synthesis of mevalonate, a precursor of ubiquinone that is a central
compound of the mitochondrial respiratory chain. The main adverse effect of statins is a toxic …

Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway

…, V Ruiz-Bonilla, M Jardí, R Gherardi… - Genes & …, 2008 - genesdev.cshlp.org
In the fatal degenerative Duchenne muscular dystrophy (DMD), skeletal muscle is progressively
replaced by fibrotic tissue. Here, we show that fibrinogen accumulates in dystrophic …

Human herpesvirus 8 infection in patients with POEMS syndrome–associated multicentric Castleman's disease

…, S Cotigny, P Gaulard, RK Gherardi - Blood, The Journal …, 1999 - ashpublications.org
The polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes (POEMS)
syndrome is a rare multisystemic disorder associated with osteosclerotic myeloma and …

Endomysial fibrosis in Duchenne muscular dystrophy: a marker of poor outcome associated with macrophage alternative activation

…, F Leturcq, JP Barbet, RK Gherardi… - … of Neuropathology & …, 2009 - academic.oup.com
There is considerable interindividual variability in motor function among patients with Duchenne
muscular dystrophy (DMD); moreover, pathogenetic mechanisms of motor dysfunction …

[PDF][PDF] Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal

…, S Valable, FJ Authier, MA Rudnicki, RK Gherardi… - Cell stem cell, 2009 - cell.com
Mechanisms governing muscle satellite cell withdrawal from cell cycle to enter into quiescence
remain poorly understood. We studied the role of angiopoietin 1 (Ang1) and its receptor …