Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth
in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals …

Idiopathic infantile arterial calcification (IIAC; OMIM 208000) is characterized by calcification
of the internal elastic lamina of muscular arteries and stenosis due to myointimal proliferation…

Tissue-nonspecific alkaline phosphatase (TNAP) hydrolyzes the mineralization inhibitor
inorganic pyrophosphate (PP i ). Deletion of the TNAP gene (Akp2) in mice results in …

… Robert Terkeltaub; the photographs on the top and bottom right were provided by Dr. …
Terkeltaub had full access to all of the data in the study and takes responsibility for the integrity of …

Objective Despite widespread use of colchicine, the evidence basis for oral colchicine
therapy and dosing in acute gout remains limited. The aim of this trial was to compare low‐dose …

Chronic, low-grade inflammation in osteoarthritis (OA) contributes to symptoms and disease
progression. Effective disease-modifying OA therapies are lacking, but better understanding …

In response to a request for proposal from the American College of Rheumatology (ACR), our
group was charged with developing nonpharmacologic and pharmacologic guidelines for …

Chronic macrophage-mediated inflammation is central to atherosclerosis. A role of the
monocyte chemotactic and activating CC chemokine JE/monocyte chemotactic protein-1 has …

Objective In gout, incompletely defined molecular factors alter recognition of dormant articular
and bursal monosodium urate monohydrate (MSU) crystal deposits, thereby inducing self‐…

Inorganic pyrophosphate (PP i ) regulates certain intracellular functions and extracellular
crystal deposition. PP i is produced, degraded, and transported by specialized mechanisms. …