A unique population of IgG-expressing plasma cells lacking CD19 is enriched in human bone marrow

…, K Luda, AA Kühl, R Engelmann… - Blood, The Journal …, 2015 - ashpublications.org
Specific serum antibodies mediating humoral immunity and autoimmunity are provided by
mature plasma cells (PC) residing in the bone marrow (BM), yet their dynamics and …

Senescence determines the fate of activated rat pancreatic stellate cells

…, M Walther, M Fischer, R Engelmann… - Journal of cellular …, 2012 - Wiley Online Library
In chronic pancreatitis ( CP ), persistent activation of pancreatic stellate cells ( PSC ) converts
wound healing into a pathological process resulting in organ fibrosis. Here, we have …

[HTML][HTML] Interplay between P. gingivalis, F. nucleatum and A. actinomycetemcomitans in murine alveolar bone loss, arthritis onset and progression

…, J Volzke, K Kriebel, C Hieke, R Engelmann… - Scientific reports, 2018 - nature.com
Increasing evidence supports the association of periodontitis with rheumatoid arthritis. Even
though a prominent role has been postulated for Porphyromonas gingivalis, many bacterial …

[HTML][HTML] 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis

…, T Claudel, M Loebermann, R Engelmann… - Journal of …, 2015 - Elsevier
Background & Aims Intrahepatic granuloma formation and fibrosis characterize the pathological
features of Schistosoma mansoni infection. Based on previously observed substantial …

[HTML][HTML] Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss

…, J Volzke, J Bull, S Kneitz, R Engelmann… - Scientific reports, 2019 - nature.com
Recent studies indicate a causal relationship between the periodontal pathogen P. gingivalis
and rheumatoid arthritis involving the production of autoantibodies against citrullinated …

Expert-independent classification of mature B-cell neoplasms using standardized flow cytometry: a multicentric study

S Böttcher, R Engelmann, G Grigore… - Blood …, 2022 - ashpublications.org
Reproducible expert-independent flow-cytometric criteria for the differential diagnoses between
mature B-cell neoplasms are lacking. We developed an algorithm-driven classification …

[HTML][HTML] Transcriptome alterations in peripheral blood B cells of patients with multiple sclerosis receiving immune reconstitution therapy

…, N Boxberger, E Putscher, R Engelmann… - Journal of …, 2023 - Springer
Background Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenerative
disease that leads to irreversible damage to the brain and spinal cord. The goal of so-called "…

[HTML][HTML] Human dental stem cells suppress PMN activity after infection with the periodontopathogens Prevotella intermedia and Tannerella forsythia

C Hieke, K Kriebel, R Engelmann, B Müller-Hilke… - Scientific reports, 2016 - nature.com
Periodontitis is characterized by inflammation associated with the colonization of different
oral pathogens. We here aimed to investigate how bacteria and host cells shape their …

Vector-based SARS-CoV-2 vaccination is associated with improved T-cell responses in hematological neoplasia

R Engelmann, N Jaekel, S Jotschke… - Blood …, 2023 - ashpublications.org
In order to elucidate mechanisms for severe acute respiratory syndrome coronavirus 2
vaccination success in hematological neoplasia, we, herein, provide a comprehensive …

[HTML][HTML] Single-sex infection with female Schistosoma mansoni cercariae mitigates hepatic fibrosis after secondary infection

…, M Loebermann, R Engelmann… - PLoS neglected …, 2017 - journals.plos.org
Background Infection with Schistosoma spp. affects more than 258 million people worldwide.
Current treatment strategies are mainly based on the anthelmintic Praziquantel, which is …