[HTML][HTML] Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition

…, K Natarajan, I Nuamah, T Li, R Aranda… - … England Journal of …, 2005 - Mass Medical Soc
Background A substantial number of patients with rheumatoid arthritis have an inadequate
or unsustained response to tumor necrosis factor α (TNF-α) inhibitors. We conducted a …

Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve‐month results of a phase IIb, double‐blind, randomized, placebo …

…, JC Becker, T Li, IF Nuamah, R Aranda… - … : Official Journal of …, 2005 - Wiley Online Library
Objective To determine the clinical efficacy, safety, and immunogenicity of abatacept (CTLA‐4Ig),
a selective costimulation modulator, in patients with rheumatoid arthritis (RA) that has …

[HTML][HTML] Ozanimod induction and maintenance treatment for ulcerative colitis

…, M Cravets, PA Frohna, R Aranda… - … England Journal of …, 2016 - Mass Medical Soc
Background Ozanimod (RPC1063) is an oral agonist of the sphingosine-1-phosphate
receptor subtypes 1 and 5 that induces peripheral lymphocyte sequestration, potentially …

Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients.

R Aranda, BC Sydora, PL McAllister… - … (Baltimore, Md.: 1950 …, 1997 - journals.aai.org
Transfer of specific T lymphocyte subsets isolated from the spleens of healthy donor mice
into immunodeficient SCID mice leads to chronic intestinal inflammation with characteristics …

Mice with combined disruption of Gpx1 andGpx2 genes have colitis

RS Esworthy, R Aranda, MG Martín… - American Journal …, 2001 - journals.physiology.org
Glutathione peroxidase (GPX)-1 and gastrointestinal (GI) epithelium-specific GPX (GPX-GI),
encoded byGpx1 and Gpx2, provide most GPX activity in GI epithelium. Although …

Altered immune responses in interleukin 10 transgenic mice

…, S Sharma, SM Dubinett, SHY Wei, R Aranda… - The Journal of …, 1997 - rupress.org
Interleukin (IL)-10 is a pleiotropic cytokine which inhibits a broad array of immune parameters
including T helper cell type 1 (Th1) cytokine production, antigen presentation, and …

[HTML][HTML] RPC4046, a monoclonal antibody against IL13, reduces histologic and endoscopic activity in patients with eosinophilic esophagitis

…, DN Penenberg, C Li, GJ Opiteck, A Olson, R Aranda… - Gastroenterology, 2019 - Elsevier
Background & aims Eosinophilic esophagitis (EoE) is a chronic, esophageal, type 2 inflammatory
response associated with increased serum levels of interleukin 13 (IL13), which might …

Mesenteric B cells centrally inhibit CD4+ T cell colitis through interaction with regulatory T cell subsets

…, O Turovskaya, K Spricher, R Aranda… - Proceedings of the …, 2005 - National Acad Sciences
Inflammatory bowel disease reflects an aberrant mucosal CD4 + T cell response to commensal
enteric bacteria. In addition to regulatory T cell subsets, recent studies have revealed a …

Abatacept inhibits progression of structural damage in rheumatoid arthritis: results from the long-term extension of the AIM trial

…, R Westhovens, JC Becker, R Aranda… - Annals of the …, 2008 - ard.bmj.com
Objective: Assess the effect of abatacept on progression of structural damage over 2 years
in patients with rheumatoid arthritis who had an inadequate response to methotrexate. …

Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study

…, X Tao, LA Xu, L Salter-Cid, S Gujrathi, R Aranda… - Gut, 2014 - gut.bmj.com
Objective Interferon-γ-inducible protein-10 (IP-10 or CXCL10) plays a role in inflammatory
cell migration and epithelial cell survival and migration. It is expressed in higher levels in the …