Objective Autoantibodies have been demonstrated in single serum samples from healthy
subjects up to 10 years before they developed rheumatoid arthritis (RA). However, the time …

… Prevoo ML, van’t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL.
Modified disease activity index that include twenty-eight joint counts. Arthritis Rheum1995;38:44–8. …

… Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma
IE, de Koning MH, et al. Specific autoantibodies precede the symptoms of rheumatoid arthritis: …

… We thank Margret de Koning and Roel Heijmans for their technical assistance and Mike
Peters for critically reading the manuscript. Funding This study is financially supported by the …

… of rheumatoid arthritis - van de Stadt - 2011 - Arthritis & Rheumatism - Wiley Online Library
… LA van de Stadt had full access to all of the data in the study and takes responsibility for the …

Objectives: To examine whether treatment with anti-tumour necrosis factor (TNF) α prevents
loss of bone mineral density (BMD) at the spine and hip (generalised) and in the hands (local…

Background: The anti-cyclic citrullinated peptide (CCP) test has a high sensitivity and
specificity for rheumatoid arthritis, although CCP is not the physiological target of the …

Objective We previously reported that approximately half of the patients with rheumatoid
arthritis (RA) have specific serologic abnormalities (elevated serum concentrations of IgM …

… Schellekens GA, de Jong BAW, van den Hoogen FHJ, van de Putte LBA. Citrulline is an
essential constituent of antigenic determinants recognised by rheumatoid arthritis-specific …

Objectives To determine the fine specificity of anti-citrullinated protein antibodies (ACPA) in
the early phase of arthritis development, the ACPA repertoire in arthralgia patients and the …