Integrative analysis reveals a molecular stratification of systemic autoimmune diseases

…, R Lopez‐Pedrera, R OrtegaCastro… - Arthritis & …, 2021 - Wiley Online Library
Objective Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes
early diagnosis and effective treatment, issues that may be addressed if patients could be …

Diagnostic potential of NETosis-derived products for disease activity, atherosclerosis and therapeutic effectiveness in Rheumatoid Arthritis patients

…, MC Castro-Villegas, R Ortega-Castro… - Journal of …, 2017 - Elsevier
Objectives 1) To assess the association of NETosis and NETosis-derived products with the
activity of the disease and the development of cardiovascular disease in RA; 2) To evaluate …

Evaluation of quality of life in patients with axial spondyloarthritis and its association with disease activity, functionality, mobility, and structural damage

…, MC Castro-Villegas, R Ortega-Castro… - Clinical …, 2018 - Springer
… Therefore, we were able to determine the Pearson correlation coefficient r for each of the
comparisons, classifying them as moderate, strong, or very strong correlations if the value of r

[HTML][HTML] Predictors of progression and mortality in patients with prevalent rheumatoid arthritis and interstitial lung disease: a prospective cohort study

…, L Pérez-Albaladejo, R Ortega-Castro… - Journal of Clinical …, 2021 - mdpi.com
Objectives: To describe a prospective cohort of patients with rheumatoid arthritis associated
with interstitial lung disease (RA-ILD) and identify risk factors associated with disease …

[HTML][HTML] Irisin as a novel biomarker of subclinical atherosclerosis, cardiovascular risk and severe disease in axial spondyloarthritis

…, N Barbarroja, R Ortega-Castro… - Frontiers in …, 2022 - frontiersin.org
Introduction Patients with axial spondyloarthritis (axSpA) have a high disease burden mainly
due to the rheumatic disease itself, and also exhibit accelerated atherosclerosis, that leads …

[HTML][HTML] Treatment adherence during the COVID-19 pandemic and the impact of confinement on disease activity and emotional status: a survey in 644 rheumatic …

…, P Armenteros-Ortiz, R Ortega-Castro… - Joint Bone …, 2021 - ncbi.nlm.nih.gov
The Spanish lockdown during the COVID-19 pandemic has been one of the strictest among
European countries since neither short walks nor individual sports were allowed for 7 weeks…

A proinflammatory cytokine network profile in Th1/Type 1 effector b cells delineates a common group of patients in four systemic autoimmune diseases

…, H Navarro‐Linares, R OrtegaCastro… - Arthritis & …, 2021 - Wiley Online Library
Objective The effector T cell and B cell cytokine networks have been implicated in the
pathogenesis of systemic autoimmune diseases, but the association of these cytokine networks …

Preclinical Characterization of Pharmacologic NAD+ Boosting as a Promising Therapeutic Approach in Rheumatoid Arthritis

…, N Barbarroja, J Calvo, R OrtegaCastro… - Arthritis & …, 2023 - Wiley Online Library
Objective We analyzed NAD + metabolism in patients with rheumatoid arthritis (RA), its
association with disease activity and clinical outcomes of RA, and the therapeutic potential of …

[HTML][HTML] Molecular characterization of monocyte subsets reveals specific and distinctive molecular signatures associated with cardiovascular disease in rheumatoid …

P Ruiz-Limon, R Ortega-Castro, N Barbarroja… - Frontiers in …, 2019 - frontiersin.org
Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking
project PRECISESADS framework, aimed at functionally characterize the monocyte …

[HTML][HTML] Integrative clinical, molecular, and computational analysis identify novel biomarkers and differential profiles of anti-TNF response in rheumatoid arthritis

…, D Ruiz-Vilchez, R Ortega-Castro… - Frontiers in …, 2021 - frontiersin.org
Background: This prospective multicenter study developed an integrative clinical and molecular
longitudinal study in Rheumatoid Arthritis (RA) patients to explore changes in serologic …